Carboxylic Acid (Bio)Isosteres in Drug Design

The carboxylic acid functional group can be an important constituent of a pharmacophore, however, the presence of this moiety can also be responsible for significant drawbacks, including metabolic instability, toxicity, as well as limited passive diffusion across biological membranes. To avoid some...

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Veröffentlicht in:	ChemMedChem 2013-03, Vol.8 (3), p.385-395
Hauptverfasser:	Ballatore, Carlo, Huryn, Donna M., Smith III, Amos B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Analytical chemistry Azoles - chemistry Azoles - metabolism bioisosteres carboxylic acids Carboxylic Acids - chemistry Carboxylic Acids - metabolism Drug Design Furans - chemistry Furans - metabolism Hydroxamic Acids - chemistry Hydroxamic Acids - metabolism isosteric replacement Ketones - chemistry Ketones - metabolism Kinetics Phosphorous Acids - chemistry Phosphorous Acids - metabolism Sulfonamides - chemistry Sulfonamides - metabolism Sulfonic Acids - chemistry Sulfonic Acids - metabolism
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