Triblock copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting

Abstract A key challenge in developing nanoplatform-based molecular imaging is to achieve an optimal pharmacokinetic profile to allow sufficient targeting and to avoid rapid clearance by the reticuloendothelial system (RES). In the present study, iron oxide nanoparticles (IONPs) were coated with a P...

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Veröffentlicht in:	Biomaterials 2009-12, Vol.30 (36), p.6912-6919
Hauptverfasser:	Chen, Kai, Xie, Jin, Xu, Hengyi, Behera, Deepak, Michalski, Mark H, Biswal, Sandip, Wang, Andrew, Chen, Xiaoyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Biocompatible Materials Cell Line, Tumor Dentistry Ferric Compounds - chemistry Ferric Compounds - metabolism Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism Glioblastoma - metabolism Humans Integrin α vβ 3 Integrins - metabolism Iron oxide nanoparticles (IONPs) Magnetic resonance imaging (MRI) Materials Testing Mice Molecular Structure Nanoparticles - chemistry Near-infrared fluorescence (NIRF) imaging Neoplasms - metabolism Oligopeptides - metabolism Polymers - chemistry Polymers - metabolism RGD peptide Surface Properties Tissue Distribution Transplantation, Heterologous Tumor targeting
Online-Zugang:	Volltext
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