CASK Functions as a Mg2+-independent neurexin kinase

CASK is a unique MAGUK protein that contains an N-terminal CaM-kinase domain besides the typical MAGUK domains. The CASK CaM-kinase domain is presumed to be a catalytically inactive pseudokinase because it lacks the canonical DFG motif required for Mg2+ binding that is thought to be indispensable fo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2008-04, Vol.133 (2), p.328-339
Hauptverfasser:	Mukherjee, Konark, Sharma, Manu, Urlaub, Henning, Bourenkov, Gleb P, Jahn, Reinhard, Südhof, Thomas C, Wahl, Markus C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cells, Cultured Crystallography, X-Ray Glycoproteins - metabolism Guanylate Kinases - chemistry Guanylate Kinases - metabolism Humans Magnesium - metabolism Mice Models, Molecular Neurons - metabolism Neuropeptides - metabolism Nucleotides - metabolism Protein Binding Protein Structure, Tertiary Rats Sequence Homology, Amino Acid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!