An inducible transgene expression system for zebrafish and chick

We have generated an inducible system to control the timing of transgene expression in zebrafish and chick. An estrogen receptor variant (ERT2) fused to the GAL4 transcriptional activator rapidly and robustly activates transcription within 3 hours of treatment with the drug 4-hydroxy-tamoxifen (4-OH...

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Veröffentlicht in:	Development (Cambridge) 2013-05, Vol.140 (10), p.2235-2243
Hauptverfasser:	Gerety, Sebastian S, Breau, Marie A, Sasai, Noriaki, Xu, Qiling, Briscoe, James, Wilkinson, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Chick Embryo Crosses, Genetic Danio rerio Developmental Biology - methods Freshwater Gene Expression Regulation, Developmental HEK293 Cells Humans Immunohistochemistry In Situ Hybridization Phenotype Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Tamoxifen - analogs & derivatives Tamoxifen - pharmacology Techniques and Resources Transgenes Zebrafish Zebrafish Proteins - metabolism
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