Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia

Hypoglycemia occurs frequently during intensive insulin therapy in patients with both type 1 and type 2 diabetes and remains the single most important obstacle in achieving tight glycemic control. Using a rodent model of hypoglycemia, we demonstrated that exposure to antecedent recurrent hypoglycemi...

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Veröffentlicht in:	The Journal of clinical investigation 2013-05, Vol.123 (5), p.1988-1998
Hauptverfasser:	Herzog, Raimund I, Jiang, Lihong, Herman, Peter, Zhao, Chen, Sanganahalli, Basavaraju G, Mason, Graeme F, Hyder, Fahmeed, Rothman, Douglas L, Sherwin, Robert S, Behar, Kevin L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical research Blood Glucose - metabolism Brain - embryology Care and treatment Cell metabolism Development and progression Diabetes Dose-Response Relationship, Drug Electrophysiology Glucose Glucose - metabolism Glucose Clamp Technique Health aspects Humans Hyperglycemia Hypoglycemia Hypoglycemia - metabolism Hypoglycemia - physiopathology Insulin - metabolism Lactates Lactic Acid - metabolism Magnetic Resonance Spectroscopy Male Metabolism Neurons Neurons - metabolism Oxygen - metabolism Physiological aspects Rats Rats, Sprague-Dawley Recurrence Rodents
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