Active Component of Danshen (Salvia miltiorrhiza Bunge), Tanshinone I, Attenuates Lung Tumorigenesis via Inhibitions of VEGF, Cyclin A, and Cyclin B Expressions

Tanshinone I (T1) and tanshinone II (T2) are the major diterpenes isolated from Danshen (Salvia miltiorrhiza Bunge). Three human lung adenocarcinoma cell lines, A549, CL1-0, and CL1-5, were treated with T1 and T2 for the in vitro antitumor test. Results showed that T1 was more effective than T2 in i...

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Veröffentlicht in:	Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-10
Hauptverfasser:	Tung, Yu-Tang, Chen, Hsiao-Ling, Lee, Cheng-Yu, Chou, Yu-Ching, Lee, Po-Ying, Tsai, Hsin-Chung, Lin, Yi-Ling, Chen, Chuan-Mu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Angiogenesis Antitumor activity Apoptosis Brain tumors Breast cancer Cancer therapies Cardiovascular disease Cell cycle Cell lines Conditioning Cyclin A Cyclin B Cytokines Cytotoxicity Diterpenes Embryos Epidemiology Kinases Leukemia Lung cancer Medical research Metastasis Mice Monocytes Monocytic leukemia Proteins Psychedelic drugs Salvia miltiorrhiza Transgenic animals Transgenic mice Tumor cell lines Tumorigenesis Vascular endothelial growth factor
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