Integrating qPLM and biomechanical test data with an anisotropic fiber distribution model and predictions of TGF-β1 and IGF-1 regulation of articular cartilage fiber modulus

A continuum mixture model with distinct collagen (COL) and glycosaminoglycan elastic constituents was developed for the solid matrix of immature bovine articular cartilage. A continuous COL fiber volume fraction distribution function and a true COL fiber elastic modulus ([Formula: see text] were use...

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Veröffentlicht in:	Biomechanics and modeling in mechanobiology 2013-11, Vol.12 (6), p.1073-1088
Hauptverfasser:	Stender, Michael E, Raub, Christopher B, Yamauchi, Kevin A, Shirazi, Reza, Vena, Pasquale, Sah, Robert L, Hazelwood, Scott J, Klisch, Stephen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anisotropy Biomechanical Phenomena - drug effects Cartilage, Articular - drug effects Cartilage, Articular - physiology Cattle Elastic Modulus - drug effects Fibrillar Collagens - metabolism Glycosaminoglycans - metabolism Insulin-Like Growth Factor I - pharmacology Microscopy, Polarization - methods Models, Biological Space life sciences Transforming Growth Factor beta1 - pharmacology
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