Pre-operative hypoalbuminaemia predicts poor overall survival in rectal cancer: a retrospective cohort analysis
Serum albumin is a marker of nutrition and inflammation. It has recently emerged as a predictor of outcome after surgery for rectal cancer. Our aim was to evaluate if pre-operative serum albumin would predict survival after resection for rectal cancer. 226 Patients with rectal cancer of all stages u...
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| Veröffentlicht in: | BMC clinical pathology 2013-04, Vol.13 (1), p.12-12, Article 12 |
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| creator | Chandrasinghe, Pramodh C Ediriweera, Dileepa S Kumarage, Sumudu K Deen, Kemal I |
| description | Serum albumin is a marker of nutrition and inflammation. It has recently emerged as a predictor of outcome after surgery for rectal cancer. Our aim was to evaluate if pre-operative serum albumin would predict survival after resection for rectal cancer.
226 Patients with rectal cancer of all stages undergoing resection with curative intent were studied. Kaplan-Meier curves analysed survival based on a pre-operative albumin level of 35 g/L. We sought for significant associations of survival with age, sex, stage, tumour site, use of neoadjuvant chemoradiation, microscopic positive resection margins, differentiation, angio, peri-neural, and lymphovascular invasion using individual variable analysis. Multifactorial analysis was performed using type III analysis with Weibull hazard model and Cox-proportional hazard model. Significance was assigned to a P value |
| doi_str_mv | 10.1186/1472-6890-13-12 |
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226 Patients with rectal cancer of all stages undergoing resection with curative intent were studied. Kaplan-Meier curves analysed survival based on a pre-operative albumin level of <35 g/L vs. >35 g/L. We sought for significant associations of survival with age, sex, stage, tumour site, use of neoadjuvant chemoradiation, microscopic positive resection margins, differentiation, angio, peri-neural, and lymphovascular invasion using individual variable analysis. Multifactorial analysis was performed using type III analysis with Weibull hazard model and Cox-proportional hazard model. Significance was assigned to a P value <0.05.
Of 226 patients (median age- 59 years; range 19 - 88, Male - 54%), forty five (20%) had an albumin level < 35 g/L and was associated with a poor overall survival (P = 0.02). Mean survival in months for <35 g/L vs. >35 g/L was 64.7 (SE - 9.3) vs. 95.8 (SE - 7.0) and 5 year overall survival rates were 49% and 69%. Individual variable analysis revealed age, circumferential margin, stage, perineural, lympho-vascular and angio invasion to be also significant. With multifactorial analysis hypoalbuminaemia (HR = 0.58; 95% CI: 0.35 - 0.95, P = 0.03), advanced stage (HR = 2.0; 95% CI: 1.26 - 3.23, P < 0.01) and positive circumferential margin (HR = 2.2; 95% CI: 1.26 - 3.89, P < 0.01) remained significant.
Preoperative hypoalbuminaemia is an independent risk factor for poor overall survival in rectal cancer. Advanced tumour stage and circumferential margin positivity were the other associations with poor survival.]]></description><identifier>ISSN: 1472-6890</identifier><identifier>EISSN: 1472-6890</identifier><identifier>DOI: 10.1186/1472-6890-13-12</identifier><identifier>PMID: 23590192</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Abdomen ; Acquisitions & mergers ; Albumin ; Biological markers ; Cancer ; Care and treatment ; Colorectal cancer ; Confidence intervals ; Diagnosis ; Health aspects ; Mortality ; Oncology, Experimental ; Patient outcomes ; Physiological aspects ; Proteins ; Risk factors ; Serum albumin ; Surgery ; Survival analysis ; Teaching hospitals</subject><ispartof>BMC clinical pathology, 2013-04, Vol.13 (1), p.12-12, Article 12</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Chandrasinghe et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Chandrasinghe et al.; licensee BioMed Central Ltd. 2013 Chandrasinghe et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b613t-fc22ee14c23a2ee3ad0735a64ca19cd23dc7c75a8255109cd73ba41ecfe409b83</citedby><cites>FETCH-LOGICAL-b613t-fc22ee14c23a2ee3ad0735a64ca19cd23dc7c75a8255109cd73ba41ecfe409b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637439/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637439/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,24801,27924,27925,53791,53793,75738,75739</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23590192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chandrasinghe, Pramodh C</creatorcontrib><creatorcontrib>Ediriweera, Dileepa S</creatorcontrib><creatorcontrib>Kumarage, Sumudu K</creatorcontrib><creatorcontrib>Deen, Kemal I</creatorcontrib><title>Pre-operative hypoalbuminaemia predicts poor overall survival in rectal cancer: a retrospective cohort analysis</title><title>BMC clinical pathology</title><addtitle>BMC Clin Pathol</addtitle><description><![CDATA[Serum albumin is a marker of nutrition and inflammation. It has recently emerged as a predictor of outcome after surgery for rectal cancer. Our aim was to evaluate if pre-operative serum albumin would predict survival after resection for rectal cancer.
226 Patients with rectal cancer of all stages undergoing resection with curative intent were studied. Kaplan-Meier curves analysed survival based on a pre-operative albumin level of <35 g/L vs. >35 g/L. We sought for significant associations of survival with age, sex, stage, tumour site, use of neoadjuvant chemoradiation, microscopic positive resection margins, differentiation, angio, peri-neural, and lymphovascular invasion using individual variable analysis. Multifactorial analysis was performed using type III analysis with Weibull hazard model and Cox-proportional hazard model. Significance was assigned to a P value <0.05.
Of 226 patients (median age- 59 years; range 19 - 88, Male - 54%), forty five (20%) had an albumin level < 35 g/L and was associated with a poor overall survival (P = 0.02). Mean survival in months for <35 g/L vs. >35 g/L was 64.7 (SE - 9.3) vs. 95.8 (SE - 7.0) and 5 year overall survival rates were 49% and 69%. Individual variable analysis revealed age, circumferential margin, stage, perineural, lympho-vascular and angio invasion to be also significant. With multifactorial analysis hypoalbuminaemia (HR = 0.58; 95% CI: 0.35 - 0.95, P = 0.03), advanced stage (HR = 2.0; 95% CI: 1.26 - 3.23, P < 0.01) and positive circumferential margin (HR = 2.2; 95% CI: 1.26 - 3.89, P < 0.01) remained significant.
Preoperative hypoalbuminaemia is an independent risk factor for poor overall survival in rectal cancer. Advanced tumour stage and circumferential margin positivity were the other associations with poor survival.]]></description><subject>Abdomen</subject><subject>Acquisitions & mergers</subject><subject>Albumin</subject><subject>Biological markers</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Colorectal cancer</subject><subject>Confidence intervals</subject><subject>Diagnosis</subject><subject>Health aspects</subject><subject>Mortality</subject><subject>Oncology, Experimental</subject><subject>Patient outcomes</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Risk factors</subject><subject>Serum albumin</subject><subject>Surgery</subject><subject>Survival analysis</subject><subject>Teaching hospitals</subject><issn>1472-6890</issn><issn>1472-6890</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kk1v1DAQhiMEoqVw5oYiceGS1h9JnHBAKhUflSq1BzhbE2fSdeXEwU4i7b9nwpalWxX54NHrZ17PjJ0kbzk75bwqz3iuRFZWNcu4zLh4lhzvlecP4qPkVYx3jHFVcfEyORKyqBmvxXHibwJmfsQAk10w3WxHD66ZezsA9hbSMWBrzRTT0fuQ-oVA59I4h8Uu4FI7pAHNRJGBwWD4mAIJU_BxJHl1NH7jw5TCAG4bbXydvOjARXxzv58kP79--XHxPbu6_nZ5cX6VNSWXU9YZIRB5boQECiS0TMkCytwAr00rZGuUUQVUoig4I0XJBnKOpsOc1U0lT5JPO99xbnpsDQ4TVa7HYHsIW-3B6sOTwW70rV-0LKXKZU0Gn3cGjfX_MTg8Mb7X68D1OnDNpeaCTD7cVxH8rxnjpHsbDToHA_o5EkUJRamkIvT9I_TOz4Gm9ocq67pkiv-jbsGhtkPn6W6zmurzgjBZsWpt_vQJilZLb2r8gJ0l_SDhbJdg6OViwG7fJ6dW6KM90dm7h_Pd839_lvwNe93Qcw</recordid><startdate>20130416</startdate><enddate>20130416</enddate><creator>Chandrasinghe, Pramodh C</creator><creator>Ediriweera, Dileepa S</creator><creator>Kumarage, Sumudu K</creator><creator>Deen, Kemal I</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130416</creationdate><title>Pre-operative hypoalbuminaemia predicts poor overall survival in rectal cancer: a retrospective cohort analysis</title><author>Chandrasinghe, Pramodh C ; Ediriweera, Dileepa S ; Kumarage, Sumudu K ; Deen, Kemal I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b613t-fc22ee14c23a2ee3ad0735a64ca19cd23dc7c75a8255109cd73ba41ecfe409b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abdomen</topic><topic>Acquisitions & mergers</topic><topic>Albumin</topic><topic>Biological markers</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Colorectal cancer</topic><topic>Confidence intervals</topic><topic>Diagnosis</topic><topic>Health aspects</topic><topic>Mortality</topic><topic>Oncology, Experimental</topic><topic>Patient outcomes</topic><topic>Physiological aspects</topic><topic>Proteins</topic><topic>Risk factors</topic><topic>Serum albumin</topic><topic>Surgery</topic><topic>Survival analysis</topic><topic>Teaching hospitals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chandrasinghe, Pramodh C</creatorcontrib><creatorcontrib>Ediriweera, Dileepa S</creatorcontrib><creatorcontrib>Kumarage, Sumudu K</creatorcontrib><creatorcontrib>Deen, Kemal I</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chandrasinghe, Pramodh C</au><au>Ediriweera, Dileepa S</au><au>Kumarage, Sumudu K</au><au>Deen, Kemal I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pre-operative hypoalbuminaemia predicts poor overall survival in rectal cancer: a retrospective cohort analysis</atitle><jtitle>BMC clinical pathology</jtitle><addtitle>BMC Clin Pathol</addtitle><date>2013-04-16</date><risdate>2013</risdate><volume>13</volume><issue>1</issue><spage>12</spage><epage>12</epage><pages>12-12</pages><artnum>12</artnum><issn>1472-6890</issn><eissn>1472-6890</eissn><abstract><![CDATA[Serum albumin is a marker of nutrition and inflammation. It has recently emerged as a predictor of outcome after surgery for rectal cancer. Our aim was to evaluate if pre-operative serum albumin would predict survival after resection for rectal cancer.
226 Patients with rectal cancer of all stages undergoing resection with curative intent were studied. Kaplan-Meier curves analysed survival based on a pre-operative albumin level of <35 g/L vs. >35 g/L. We sought for significant associations of survival with age, sex, stage, tumour site, use of neoadjuvant chemoradiation, microscopic positive resection margins, differentiation, angio, peri-neural, and lymphovascular invasion using individual variable analysis. Multifactorial analysis was performed using type III analysis with Weibull hazard model and Cox-proportional hazard model. Significance was assigned to a P value <0.05.
Of 226 patients (median age- 59 years; range 19 - 88, Male - 54%), forty five (20%) had an albumin level < 35 g/L and was associated with a poor overall survival (P = 0.02). Mean survival in months for <35 g/L vs. >35 g/L was 64.7 (SE - 9.3) vs. 95.8 (SE - 7.0) and 5 year overall survival rates were 49% and 69%. Individual variable analysis revealed age, circumferential margin, stage, perineural, lympho-vascular and angio invasion to be also significant. With multifactorial analysis hypoalbuminaemia (HR = 0.58; 95% CI: 0.35 - 0.95, P = 0.03), advanced stage (HR = 2.0; 95% CI: 1.26 - 3.23, P < 0.01) and positive circumferential margin (HR = 2.2; 95% CI: 1.26 - 3.89, P < 0.01) remained significant.
Preoperative hypoalbuminaemia is an independent risk factor for poor overall survival in rectal cancer. Advanced tumour stage and circumferential margin positivity were the other associations with poor survival.]]></abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23590192</pmid><doi>10.1186/1472-6890-13-12</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; BioMedCentral; PubMed Central; Springer Nature OA/Free Journals |
| subjects | Abdomen Acquisitions & mergers Albumin Biological markers Cancer Care and treatment Colorectal cancer Confidence intervals Diagnosis Health aspects Mortality Oncology, Experimental Patient outcomes Physiological aspects Proteins Risk factors Serum albumin Surgery Survival analysis Teaching hospitals |
| title | Pre-operative hypoalbuminaemia predicts poor overall survival in rectal cancer: a retrospective cohort analysis |
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