Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress

FGF21 is a promising intervention therapy for metabolic diseases as fatty liver, obesity and diabetes. Recent results suggest that FGF21 is highly expressed in hepatocytes under metabolic stress caused by starvation, hepatosteatosis, obesity and diabetes. Hepatic FGF21 elicits metabolic benefits by...

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Veröffentlicht in:	BMC gastroenterology 2013-04, Vol.13 (1), p.67-67, Article 67
Hauptverfasser:	Yang, Chaofeng, Lu, Weiqin, Lin, Tao, You, Pan, Ye, Min, Huang, Yanqing, Jiang, Xianhan, Wang, Cong, Wang, Fen, Lee, Mong-Hong, Yeung, Sai-Ching J, Johnson, Randy L, Wei, Chongjuan, Tsai, Robert Y, Frazier, Marsha L, McKeehan, Wallace L, Luo, Yongde
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal experimentation Animals Carcinogenesis Carcinoma, Hepatocellular - chemically induced Carcinoma, Hepatocellular - metabolism Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Chemical and Drug Induced Liver Injury - metabolism Diabetes therapy Diethylnitrosamine Disease Models, Animal DNA binding proteins Fibroblast growth factors Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism Gastroenterology Hepatocytes - metabolism Hospitals Humans Liver Liver - metabolism Liver - pathology Liver - surgery Liver Cirrhosis - metabolism Liver Neoplasms - chemically induced Liver Neoplasms - metabolism Male Membrane Proteins - genetics Metabolism Mice Physiological aspects Protein-Serine-Threonine Kinases - genetics Proteins Receptor, Fibroblast Growth Factor, Type 4 - genetics RNA, Messenger - metabolism Rodents STAT3 Transcription Factor - metabolism Stress, Physiological Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Type 2 diabetes
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