Posttranslational modifications of the retinoblastoma tumor suppressor protein as determinants of function

The retinoblastoma tumor suppressor protein (pRB) plays an integral role in G1-S checkpoint control and consequently is a frequent target for inactivation in cancer. The RB protein can function as an adaptor, nucleating components such as E2Fs and chromatin regulating enzymes into the same complex....

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Veröffentlicht in:	Genes & cancer 2012-11, Vol.3 (11-12), p.619-633
Hauptverfasser:	Macdonald, James I, Dick, Frederick A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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