Intracellular magnesium-dependent modulation of gap junction channels formed by neuronal connexin36

Gap junction (GJ) channels composed of Connexin36 (Cx36) are widely expressed in the mammalian CNS and form electrical synapses between neurons. Here we describe a novel modulatory mechanism of Cx36 GJ channels dependent on intracellular free magnesium ([Mg(2+)]i). We examined junctional conductance...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of neuroscience 2013-03, Vol.33 (11), p.4741-4753
Hauptverfasser:	Palacios-Prado, Nicolás, Hoge, Gregory, Marandykina, Alina, Rimkute, Lina, Chapuis, Sandrine, Paulauskas, Nerijus, Skeberdis, Vytenis A, O'Brien, John, Pereda, Alberto E, Bennett, Michael V L, Bukauskas, Feliksas F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Animals, Newborn Biophysical Phenomena - drug effects Biophysical Phenomena - physiology Cations, Divalent - metabolism Cell Line, Tumor Chelating Agents - pharmacology Connexin 26 Connexins - genetics Connexins - physiology Dose-Response Relationship, Drug Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Female Gap Junction delta-2 Protein Gap Junctions - drug effects Gap Junctions - physiology Green Fluorescent Proteins - genetics Humans In Vitro Techniques Intracellular Fluid - metabolism Ion Channel Gating - drug effects Ion Channel Gating - physiology Magnesium - metabolism Magnesium - pharmacology Male Membrane Potentials - drug effects Membrane Potentials - physiology Mice Neurons - cytology Neurons - metabolism Patch-Clamp Techniques Phosphorylation Rats Rats, Sprague-Dawley Tegmentum Mesencephali - cytology Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!