Selective and Potent Urea Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase

Cryptosporidium parvum and related species are zoonotic intracellular parasites of the intestine. Cryptosporidium is a leading cause of diarrhea in small children around the world. Infection can cause severe pathology in children and immunocompromised patients. This waterborne parasite is resistant...

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Veröffentlicht in:	Journal of medicinal chemistry 2012-09, Vol.55 (17), p.7759-7771
Hauptverfasser:	Gorla, Suresh Kumar, Kavitha, Mandapati, Zhang, Minjia, Liu, Xiaoping, Sharling, Lisa, Gollapalli, Deviprasad R, Striepen, Boris, Hedstrom, Lizbeth, Cuny, Gregory D
Format:	Artikel
Sprache:	eng
Schlagworte:	Cryptosporidium parvum - enzymology Enzyme Inhibitors - pharmacology Humans IMP Dehydrogenase - antagonists & inhibitors IMP Dehydrogenase - metabolism Structure-Activity Relationship Urea - pharmacology
Online-Zugang:	Volltext
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