Loneliness predicts pain, depression, and fatigue: Understanding the role of immune dysregulation
Summary Objective The pain, depression, and fatigue symptom cluster is an important health concern. Loneliness is a common risk factor for these symptoms. Little is known about the physiological mechanisms linking loneliness to the symptom cluster; immune dysregulation is a promising candidate. Late...
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| Veröffentlicht in: | Psychoneuroendocrinology 2013-08, Vol.38 (8), p.1310-1317 |
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| creator | Jaremka, Lisa M Fagundes, Christopher P Glaser, Ronald Bennett, Jeanette M Malarkey, William B Kiecolt-Glaser, Janice K |
| description | Summary Objective The pain, depression, and fatigue symptom cluster is an important health concern. Loneliness is a common risk factor for these symptoms. Little is known about the physiological mechanisms linking loneliness to the symptom cluster; immune dysregulation is a promising candidate. Latent herpesvirus reactivation, which is reflected by elevated herpesvirus antibody titers, provides a window into immune dysregulation. Cytomegalovirus (CMV) and Epstein–Barr virus (EBV) are two common herpesviruses. Methods Participants were 200 breast cancer survivors who were 2 months to 3 years post-treatment at the time of the study. They completed questionnaires and provided a blood sample that was assayed for CMV and EBV antibody titers. Results Lonelier participants experienced more pain, depression, and fatigue than those who felt more socially connected. Lonelier participants also had higher CMV antibody titers which, in turn, were associated with higher levels of the pain, depression, and fatigue symptom cluster. Contrary to expectations, EBV antibody titers were not associated with either loneliness or the symptom cluster. Conclusions The pain, depression, and fatigue symptom cluster is a notable clinical problem, especially among cancer survivors. Accordingly, understanding the risk factors for these symptoms is important. The current study suggests that loneliness enhances risk for immune dysregulation and the pain, depression, and fatigue symptom cluster. The present data also provide a glimpse into the pathways through which loneliness may impact health. |
| doi_str_mv | 10.1016/j.psyneuen.2012.11.016 |
| format | Article |
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Loneliness is a common risk factor for these symptoms. Little is known about the physiological mechanisms linking loneliness to the symptom cluster; immune dysregulation is a promising candidate. Latent herpesvirus reactivation, which is reflected by elevated herpesvirus antibody titers, provides a window into immune dysregulation. Cytomegalovirus (CMV) and Epstein–Barr virus (EBV) are two common herpesviruses. Methods Participants were 200 breast cancer survivors who were 2 months to 3 years post-treatment at the time of the study. They completed questionnaires and provided a blood sample that was assayed for CMV and EBV antibody titers. Results Lonelier participants experienced more pain, depression, and fatigue than those who felt more socially connected. Lonelier participants also had higher CMV antibody titers which, in turn, were associated with higher levels of the pain, depression, and fatigue symptom cluster. Contrary to expectations, EBV antibody titers were not associated with either loneliness or the symptom cluster. Conclusions The pain, depression, and fatigue symptom cluster is a notable clinical problem, especially among cancer survivors. Accordingly, understanding the risk factors for these symptoms is important. The current study suggests that loneliness enhances risk for immune dysregulation and the pain, depression, and fatigue symptom cluster. The present data also provide a glimpse into the pathways through which loneliness may impact health.</description><identifier>ISSN: 0306-4530</identifier><identifier>EISSN: 1873-3360</identifier><identifier>DOI: 10.1016/j.psyneuen.2012.11.016</identifier><identifier>PMID: 23273678</identifier><identifier>CODEN: PSYCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Aged ; Antibodies, Viral - blood ; Antibodies, Viral - immunology ; Behavioral psychophysiology ; Biological and medical sciences ; Breast Neoplasms - immunology ; Breast Neoplasms - psychology ; Cytomegalovirus ; Cytomegalovirus - immunology ; Depression ; Depression - complications ; Depression - immunology ; Depression - psychology ; Endocrinology & Metabolism ; Epstein-Barr virus ; Fatigue ; Fatigue - complications ; Fatigue - immunology ; Fatigue - psychology ; Female ; Fundamental and applied biological sciences. Psychology ; Herpesvirus ; Herpesvirus 4, Human - immunology ; Hormones and behavior ; Humans ; Immune dysregulation ; Infectious diseases ; Loneliness ; Loneliness - psychology ; Medical sciences ; Middle Aged ; Mood disorders ; Pain ; Pain - complications ; Pain - immunology ; Pain - psychology ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Survivors - psychology ; Symptom cluster ; Viral diseases</subject><ispartof>Psychoneuroendocrinology, 2013-08, Vol.38 (8), p.1310-1317</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><rights>2012 Elsevier Ltd. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c589t-910f9f4203c15d8f86ba15b8dfa7f544ad2e00dea180162895b6d3bf43a5fc233</citedby><cites>FETCH-LOGICAL-c589t-910f9f4203c15d8f86ba15b8dfa7f544ad2e00dea180162895b6d3bf43a5fc233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.psyneuen.2012.11.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27461857$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23273678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jaremka, Lisa M</creatorcontrib><creatorcontrib>Fagundes, Christopher P</creatorcontrib><creatorcontrib>Glaser, Ronald</creatorcontrib><creatorcontrib>Bennett, Jeanette M</creatorcontrib><creatorcontrib>Malarkey, William B</creatorcontrib><creatorcontrib>Kiecolt-Glaser, Janice K</creatorcontrib><title>Loneliness predicts pain, depression, and fatigue: Understanding the role of immune dysregulation</title><title>Psychoneuroendocrinology</title><addtitle>Psychoneuroendocrinology</addtitle><description>Summary Objective The pain, depression, and fatigue symptom cluster is an important health concern. Loneliness is a common risk factor for these symptoms. Little is known about the physiological mechanisms linking loneliness to the symptom cluster; immune dysregulation is a promising candidate. Latent herpesvirus reactivation, which is reflected by elevated herpesvirus antibody titers, provides a window into immune dysregulation. Cytomegalovirus (CMV) and Epstein–Barr virus (EBV) are two common herpesviruses. Methods Participants were 200 breast cancer survivors who were 2 months to 3 years post-treatment at the time of the study. They completed questionnaires and provided a blood sample that was assayed for CMV and EBV antibody titers. Results Lonelier participants experienced more pain, depression, and fatigue than those who felt more socially connected. Lonelier participants also had higher CMV antibody titers which, in turn, were associated with higher levels of the pain, depression, and fatigue symptom cluster. Contrary to expectations, EBV antibody titers were not associated with either loneliness or the symptom cluster. Conclusions The pain, depression, and fatigue symptom cluster is a notable clinical problem, especially among cancer survivors. Accordingly, understanding the risk factors for these symptoms is important. The current study suggests that loneliness enhances risk for immune dysregulation and the pain, depression, and fatigue symptom cluster. The present data also provide a glimpse into the pathways through which loneliness may impact health.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - immunology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - immunology</subject><subject>Breast Neoplasms - psychology</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - immunology</subject><subject>Depression</subject><subject>Depression - complications</subject><subject>Depression - immunology</subject><subject>Depression - psychology</subject><subject>Endocrinology & Metabolism</subject><subject>Epstein-Barr virus</subject><subject>Fatigue</subject><subject>Fatigue - complications</subject><subject>Fatigue - immunology</subject><subject>Fatigue - psychology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Herpesvirus</subject><subject>Herpesvirus 4, Human - immunology</subject><subject>Hormones and behavior</subject><subject>Humans</subject><subject>Immune dysregulation</subject><subject>Infectious diseases</subject><subject>Loneliness</subject><subject>Loneliness - psychology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Pain</subject><subject>Pain - complications</subject><subject>Pain - immunology</subject><subject>Pain - psychology</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Survivors - psychology</subject><subject>Symptom cluster</subject><subject>Viral diseases</subject><issn>0306-4530</issn><issn>1873-3360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v1DAQjRCILoW_UOWCxIGEsZ04DoeqqOJLWokD9Gw59njrJWsvdlJp_z2Odls-Lj159PzmefzeFMUFgZoA4e-29T4dPM7oawqE1oTUGX5SrIjoWMUYh6fFChjwqmkZnBUvUtoCABecPi_OKKMd451YFWodPI7OY0rlPqJxesqFcv5taTADKbmQa-VNadXkNjO-L2-8wZimjDm_KadbLGMYsQy2dLvd7LE0hxRxM4-5IfiXxTOrxoSvTud5cfPp44_rL9X62-ev1x_WlW5FP1U9AdvbhgLTpDXCCj4o0g7CWNXZtmmUoQhgUBGRP0pF3w7csME2TLVWU8bOi8uj7n4edmg0-imqUe6j26l4kEE5-e-Nd7dyE-4k49kuAlngzUkghl8zpknuXNI4jspjmJMkDeV933d9-zh1MVc0TCxj8SNVx5CyLfZhIgJyiVJu5X2UcolSEiIznBsv_v7PQ9t9dpnw-kRQSavRRuW1S394XcOJaLvMuzryMLt_5zDKpB16ncOOqCdpgnt8lsv_JHTeGZdf_YkHTNswR5-zlUQmKkF-XxZv2TtCARpgPfsNmYPXaQ</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Jaremka, Lisa M</creator><creator>Fagundes, Christopher P</creator><creator>Glaser, Ronald</creator><creator>Bennett, Jeanette M</creator><creator>Malarkey, William B</creator><creator>Kiecolt-Glaser, Janice K</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20130801</creationdate><title>Loneliness predicts pain, depression, and fatigue: Understanding the role of immune dysregulation</title><author>Jaremka, Lisa M ; Fagundes, Christopher P ; Glaser, Ronald ; Bennett, Jeanette M ; Malarkey, William B ; Kiecolt-Glaser, Janice K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c589t-910f9f4203c15d8f86ba15b8dfa7f544ad2e00dea180162895b6d3bf43a5fc233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Antibodies, Viral - blood</topic><topic>Antibodies, Viral - immunology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - immunology</topic><topic>Breast Neoplasms - psychology</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus - immunology</topic><topic>Depression</topic><topic>Depression - complications</topic><topic>Depression - immunology</topic><topic>Depression - psychology</topic><topic>Endocrinology & Metabolism</topic><topic>Epstein-Barr virus</topic><topic>Fatigue</topic><topic>Fatigue - complications</topic><topic>Fatigue - immunology</topic><topic>Fatigue - psychology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Herpesvirus</topic><topic>Herpesvirus 4, Human - immunology</topic><topic>Hormones and behavior</topic><topic>Humans</topic><topic>Immune dysregulation</topic><topic>Infectious diseases</topic><topic>Loneliness</topic><topic>Loneliness - psychology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Pain</topic><topic>Pain - complications</topic><topic>Pain - immunology</topic><topic>Pain - psychology</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Survivors - psychology</topic><topic>Symptom cluster</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jaremka, Lisa M</creatorcontrib><creatorcontrib>Fagundes, Christopher P</creatorcontrib><creatorcontrib>Glaser, Ronald</creatorcontrib><creatorcontrib>Bennett, Jeanette M</creatorcontrib><creatorcontrib>Malarkey, William B</creatorcontrib><creatorcontrib>Kiecolt-Glaser, Janice K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psychoneuroendocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jaremka, Lisa M</au><au>Fagundes, Christopher P</au><au>Glaser, Ronald</au><au>Bennett, Jeanette M</au><au>Malarkey, William B</au><au>Kiecolt-Glaser, Janice K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Loneliness predicts pain, depression, and fatigue: Understanding the role of immune dysregulation</atitle><jtitle>Psychoneuroendocrinology</jtitle><addtitle>Psychoneuroendocrinology</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>38</volume><issue>8</issue><spage>1310</spage><epage>1317</epage><pages>1310-1317</pages><issn>0306-4530</issn><eissn>1873-3360</eissn><coden>PSYCDE</coden><abstract>Summary Objective The pain, depression, and fatigue symptom cluster is an important health concern. Loneliness is a common risk factor for these symptoms. Little is known about the physiological mechanisms linking loneliness to the symptom cluster; immune dysregulation is a promising candidate. Latent herpesvirus reactivation, which is reflected by elevated herpesvirus antibody titers, provides a window into immune dysregulation. Cytomegalovirus (CMV) and Epstein–Barr virus (EBV) are two common herpesviruses. Methods Participants were 200 breast cancer survivors who were 2 months to 3 years post-treatment at the time of the study. They completed questionnaires and provided a blood sample that was assayed for CMV and EBV antibody titers. Results Lonelier participants experienced more pain, depression, and fatigue than those who felt more socially connected. Lonelier participants also had higher CMV antibody titers which, in turn, were associated with higher levels of the pain, depression, and fatigue symptom cluster. Contrary to expectations, EBV antibody titers were not associated with either loneliness or the symptom cluster. Conclusions The pain, depression, and fatigue symptom cluster is a notable clinical problem, especially among cancer survivors. Accordingly, understanding the risk factors for these symptoms is important. The current study suggests that loneliness enhances risk for immune dysregulation and the pain, depression, and fatigue symptom cluster. The present data also provide a glimpse into the pathways through which loneliness may impact health.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>23273678</pmid><doi>10.1016/j.psyneuen.2012.11.016</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Aged Antibodies, Viral - blood Antibodies, Viral - immunology Behavioral psychophysiology Biological and medical sciences Breast Neoplasms - immunology Breast Neoplasms - psychology Cytomegalovirus Cytomegalovirus - immunology Depression Depression - complications Depression - immunology Depression - psychology Endocrinology & Metabolism Epstein-Barr virus Fatigue Fatigue - complications Fatigue - immunology Fatigue - psychology Female Fundamental and applied biological sciences. Psychology Herpesvirus Herpesvirus 4, Human - immunology Hormones and behavior Humans Immune dysregulation Infectious diseases Loneliness Loneliness - psychology Medical sciences Middle Aged Mood disorders Pain Pain - complications Pain - immunology Pain - psychology Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Survivors - psychology Symptom cluster Viral diseases |
| title | Loneliness predicts pain, depression, and fatigue: Understanding the role of immune dysregulation |
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