Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

• Introduction • Perlecan: a pro‐angiogenic proteoglycan • Endorepellin, a C‐terminal fragment of perlecan with anti‐angiogenic activity • Syndecans in cancer biology • Glypicans and the control of cancer growth • Role of heparanase and proteoglycan remodelling in cancer • Decorin and growth...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2011-05, Vol.15 (5), p.1013-1031
Hauptverfasser:	Iozzo, Renato V., Sanderson, Ralph D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis Biological activity Biology Cancer Carcinogenesis Cell Proliferation Cell surface Coronary vessels Decorin endorepellin Enzymes glypican Growth factors Heparan sulfate Heparan sulfate proteoglycans heparanase Humans Kinases LG3 lumican Melanoma Metastases Myc protein Neoplasms - blood supply Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic - metabolism Perlecan Prostate Protein structure Proteins Proteoglycans - metabolism Pulmonary arteries Repressors Reviews Roles Signal Transduction small leucine‐rich proteoglycans Syndecan Tumor Microenvironment Tumors Vascularization VEGF β-Catenin
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