Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure

Evolution of H1N1 influenza A outbreaks of the past 100 years is interesting and significantly complex and details of H1N1 genetic drift remains unknown. Here we investigated the clinical characteristics and immune cross-reactivity of significant historical H1N1 strains. We infected ferrets with H1N...

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Veröffentlicht in:	Scientific reports 2013-04, Vol.3 (1), p.1698-1698, Article 1698
Hauptverfasser:	Huang, Stephen S. H., Lin, Zhen, Banner, David, León, Alberto J., Paquette, Stéphane G., Rubin, Barry, Rubino, Salvatore, Guan, Yi, Kelvin, David J., Kelvin, Alyson A.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/255/2514 631/326/421 631/326/596/1578 692/420/254 Animals Antisera Cross-reactivity Drug development Ferrets - virology Genetic drift Hemagglutinin Glycoproteins, Influenza Virus - immunology Hemagglutinins Humanities and Social Sciences Immune response Immunity, Innate - immunology Influenza A Influenza A Virus, H1N1 Subtype - classification Influenza A Virus, H1N1 Subtype - drug effects Influenza A Virus, H1N1 Subtype - immunology multidisciplinary Outbreaks Science Species Specificity Strains (organisms) Swine flu Vaccines Viral Vaccines - administration & dosage
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