Mutation and association analysis of GEN1 in breast cancer susceptibility

GEN1 was recently identified as a key Holliday junction resolvase involved in homologous recombination. Somatic truncating GEN1 mutations have been reported in two breast cancers. Together these data led to the proposition that GEN1 is a breast cancer predisposition gene. In this article we have for...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Breast cancer research and treatment 2010-11, Vol.124 (1), p.283-288
Hauptverfasser:	Turnbull, Clare, Hines, Sarah, Renwick, Anthony, Hughes, Deborah, Pernet, David, Elliott, Anna, Seal, Sheila, Warren-Perry, Margaret, Gareth Evans, D, Eccles, Diana, Stratton, Michael R, Rahman, Nazneen
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Breast cancer breast neoplasms Breast Neoplasms - genetics Brief Report Cancer Cancer genes Cancer research Case-Control Studies Chi-Square Distribution Disease susceptibility DNA Mutational Analysis DNA repair Female Gene Frequency Genes Genetic aspects Genetic Association Studies Genetic Predisposition to Disease Genetic susceptibility Genetics Gynecology. Andrology. Obstetrics Holliday Junction Resolvases - genetics Humans Mammary gland diseases Medical sciences Medicine Medicine & Public Health Mutation Oncology Pedigree Polymorphism, Single Nucleotide Risk Assessment Risk Factors Tumors United Kingdom
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!