Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation

The transcription factor inhibitor of DNA binding (Id)2 modulates T cell fate decisions, but the molecular mechanism underpinning this regulation is unclear. In this study we show that loss of Id2 cripples effector differentiation and instead programs CD8(+) T cells to adopt a memory fate with incre...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-05, Vol.190 (9), p.4585-4594
Hauptverfasser:	Masson, Frederick, Minnich, Martina, Olshansky, Moshe, Bilic, Ivan, Mount, Adele M, Kallies, Axel, Speed, Terence P, Busslinger, Meinrad, Nutt, Stephen L, Belz, Gabrielle T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - immunology Basic Helix-Loop-Helix Transcription Factors - metabolism CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Differentiation - genetics Cell Differentiation - immunology Gene Expression - immunology Hepatocyte Nuclear Factor 1-alpha Immune Regulation Immunologic Memory - genetics Immunologic Memory - immunology Inhibitor of Differentiation Protein 2 - genetics Inhibitor of Differentiation Protein 2 - immunology Inhibitor of Differentiation Protein 2 - metabolism Life Sciences Mice Mice, Inbred C57BL T Cell Transcription Factor 1 - genetics T Cell Transcription Factor 1 - immunology T Cell Transcription Factor 1 - metabolism T-Box Domain Proteins - genetics T-Box Domain Proteins - immunology T-Box Domain Proteins - metabolism
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