Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation

A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps and second, in gastric cancer, WNT activation confers a poor prognosis. However, the fun...

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Veröffentlicht in:	Oncogene 2013-04, Vol.32 (16), p.2048-2057
Hauptverfasser:	Radulescu, S, Ridgway, R A, Cordero, J, Athineos, D, Salgueiro, P, Poulsom, R, Neumann, J, Jung, A, Patel, S, Woodgett, J, Barker, N, Pritchard, D M, Oien, K, Sansom, O J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/68 631/80/86 692/420/755 692/699/67/1504/1829 Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli - metabolism Adenomatous Polyposis Coli - pathology Animals Apoptosis beta Catenin - genetics beta Catenin - metabolism Cell Biology Cell Differentiation - physiology Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cellular signal transduction Disease Models, Animal Gastric cancer Gene mutations Genetic aspects Health aspects Homeostasis Human Genetics Internal Medicine Medicine & Public Health Mice Mice, Inbred C57BL Oncology Original original-article Risk factors Signal Transduction Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Transgenes Tumors Wnt Proteins - genetics Wnt Proteins - metabolism
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