miR-155 Regulates Immune Modulatory Properties of Mesenchymal Stem Cells by Targeting TAK1-binding Protein 2

MSCs possess potent immunosuppressive capacity. We have reported that mouse MSCs inhibit T cell proliferation and function via nitric oxide. This immune regulatory capacity of MSCs is induced by the inflammatory cytokines IFNγ together with either TNFα or IL-1β. This effect of inflammatory cytokines...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2013-04, Vol.288 (16), p.11074-11079
Hauptverfasser:	Xu, Chunliang, Ren, Guangwen, Cao, Gang, Chen, Qing, Shou, Peishun, Zheng, Chunxing, Du, Liming, Han, Xiaoyan, Jiang, Menghui, Yang, Qian, Lin, Liangyu, Wang, Guan, Yu, Pengfei, Zhang, Xin, Cao, Wei, Brewer, Gary, Wang, Ying, Shi, Yufang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Adaptor Proteins, Signal Transducing - metabolism Animals Cell Biology Cell Line Gene Expression Regulation, Enzymologic - genetics Gene Expression Regulation, Enzymologic - immunology Gene Knockdown Techniques Humans Immune Tolerance - physiology Immunosuppression Interferon-gamma - genetics Interferon-gamma - immunology Interferon-gamma - metabolism Interleukin-1beta - genetics Interleukin-1beta - immunology Interleukin-1beta - metabolism Mesenchymal Stem Cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - immunology Mesenchymal Stem Cells - metabolism Mice MicroRNA MicroRNAs - genetics MicroRNAs - immunology MicroRNAs - metabolism miR-155 Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Type II - biosynthesis Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - immunology TAB2 Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!