Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment‐resistant bipolar depression

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • (R,S)‐ketamine is a phencyclidine derivative that was initially developed as an anaesthetic agent and which is currently being studied in the treatment of pain and depression. After administration, the drug is extensively N‐demethylated to (R,S)‐norketamine...

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Veröffentlicht in:	British journal of clinical pharmacology 2012-08, Vol.74 (2), p.304-314
Hauptverfasser:	Zhao, Xiaochen, Venkata, Swarajya Lakshmi Vattem, Moaddel, Ruin, Luckenbaugh, Dave A., Brutsche, Nancy E., Ibrahim, Lobna, Zarate Jr, Carlos A., Mager, Donald E., Wainer, Irving W.
Format:	Artikel
Sprache:	eng
Schlagworte:	(2S, 6S 2R, 6R)‐hydroxynorketamine (R, S)‐dehydronorketamine (R, S)‐norketamine Adult Adult and adolescent clinical studies Algorithms Antidepressive Agents - administration & dosage Antidepressive Agents - blood Antidepressive Agents - pharmacokinetics Biological and medical sciences Biotransformation bipolar depression Bipolar Disorder - blood Bipolar Disorder - drug therapy Bipolar disorders Cross-Over Studies Depression Double-Blind Method Drug Resistance Female Humans Hydroxylation Infusions, Parenteral Ketamine - administration & dosage Ketamine - analogs & derivatives Ketamine - blood Ketamine - pharmacokinetics Male Medical sciences Middle Aged Models, Biological Mood disorders Pharmacokinetics Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry stereoselectivity Young Adult
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