The study of anticancer and antifungal activities of Pistacia integerrima extract In vitro
Pistacia integerrima Stew. ex Brand (Anacardiaceae) is an ethanobotanically important plant species traditionally used in the treatment of chronic wounds, jaundice, dysentery, etc. The crude extract from Pistacia integerrima and its fractions were tested for cytotoxic activity against Michigan Cance...
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| Veröffentlicht in: | Indian journal of pharmaceutical sciences 2012-07, Vol.74 (4), p.375-379 |
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| creator | Bibi, Y Nisa, S Zia, M Waheed, A Ahmed, S Chaudhary, M |
| description | Pistacia integerrima Stew. ex Brand (Anacardiaceae) is an ethanobotanically important plant species traditionally used in the treatment of chronic wounds, jaundice, dysentery, etc. The crude extract from Pistacia integerrima and its fractions were tested for cytotoxic activity against Michigan Cancer Foundation-7 human breast cancer cell line. We have also investigated that crude stem extract of this plant also exhibits the antitumour as well as antifungal potential activities. Moreover, we have also studied that the crude extract inhibited Michigan Cancer Foundation-7 cell viability in a dose-dependent manner; the poor toxicity (1.6%) at 10 μg/ml to moderate toxicity (55.4%) at 100 μg/ml. The IC 50 values calculated were 90.9 μg/ml. The ethyl acetate and chloroform fractions at a concentration of 200 μg/ml showed ~100 and 97.4% inhibition against Michigan Cancer Foundation-7 cell line, respectively. The crude methanol extract also showed good antitumour (IC 50 125 ppm) activity, but weak antifungal activity. These findings reveal that the ethyl acetate and chloroform fractions of Pistacia integerrima are potent cytotoxic fractions, and could be an alternate candidate for the development of novel biologically active compounds. |
| doi_str_mv | 10.4103/0250-474X.107085 |
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We have also investigated that crude stem extract of this plant also exhibits the antitumour as well as antifungal potential activities. Moreover, we have also studied that the crude extract inhibited Michigan Cancer Foundation-7 cell viability in a dose-dependent manner; the poor toxicity (1.6%) at 10 μg/ml to moderate toxicity (55.4%) at 100 μg/ml. The IC 50 values calculated were 90.9 μg/ml. The ethyl acetate and chloroform fractions at a concentration of 200 μg/ml showed ~100 and 97.4% inhibition against Michigan Cancer Foundation-7 cell line, respectively. The crude methanol extract also showed good antitumour (IC 50 125 ppm) activity, but weak antifungal activity. These findings reveal that the ethyl acetate and chloroform fractions of Pistacia integerrima are potent cytotoxic fractions, and could be an alternate candidate for the development of novel biologically active compounds.</description><identifier>ISSN: 0250-474X</identifier><identifier>EISSN: 1998-3743</identifier><identifier>DOI: 10.4103/0250-474X.107085</identifier><identifier>PMID: 23626397</identifier><language>eng</language><publisher>India: Medknow Publications</publisher><subject>Anacardiaceae ; Antifungal activity ; Cell culture ; Cytotoxicity ; Drugs ; Fractionation ; In vitro ; Materia medica, Vegetable ; Microbiology ; Phytochemicals ; Plant extracts ; Product/Service Evaluations ; Short Communication ; Studies ; Testing ; Toxicity testing</subject><ispartof>Indian journal of pharmaceutical sciences, 2012-07, Vol.74 (4), p.375-379</ispartof><rights>COPYRIGHT 2012 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Jul 2012</rights><rights>Copyright: © Indian Journal of Pharmaceutical Sciences 2012</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c596c-dab71e2ea66c78d601db03c36eac81845c7ca864f174c5ff65e5075b81558f03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630737/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630737/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23626397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bibi, Y</creatorcontrib><creatorcontrib>Nisa, S</creatorcontrib><creatorcontrib>Zia, M</creatorcontrib><creatorcontrib>Waheed, A</creatorcontrib><creatorcontrib>Ahmed, S</creatorcontrib><creatorcontrib>Chaudhary, M</creatorcontrib><title>The study of anticancer and antifungal activities of Pistacia integerrima extract In vitro</title><title>Indian journal of pharmaceutical sciences</title><addtitle>Indian J Pharm Sci</addtitle><description>Pistacia integerrima Stew. ex Brand (Anacardiaceae) is an ethanobotanically important plant species traditionally used in the treatment of chronic wounds, jaundice, dysentery, etc. The crude extract from Pistacia integerrima and its fractions were tested for cytotoxic activity against Michigan Cancer Foundation-7 human breast cancer cell line. We have also investigated that crude stem extract of this plant also exhibits the antitumour as well as antifungal potential activities. Moreover, we have also studied that the crude extract inhibited Michigan Cancer Foundation-7 cell viability in a dose-dependent manner; the poor toxicity (1.6%) at 10 μg/ml to moderate toxicity (55.4%) at 100 μg/ml. The IC 50 values calculated were 90.9 μg/ml. The ethyl acetate and chloroform fractions at a concentration of 200 μg/ml showed ~100 and 97.4% inhibition against Michigan Cancer Foundation-7 cell line, respectively. The crude methanol extract also showed good antitumour (IC 50 125 ppm) activity, but weak antifungal activity. These findings reveal that the ethyl acetate and chloroform fractions of Pistacia integerrima are potent cytotoxic fractions, and could be an alternate candidate for the development of novel biologically active compounds.</description><subject>Anacardiaceae</subject><subject>Antifungal activity</subject><subject>Cell culture</subject><subject>Cytotoxicity</subject><subject>Drugs</subject><subject>Fractionation</subject><subject>In vitro</subject><subject>Materia medica, Vegetable</subject><subject>Microbiology</subject><subject>Phytochemicals</subject><subject>Plant extracts</subject><subject>Product/Service Evaluations</subject><subject>Short Communication</subject><subject>Studies</subject><subject>Testing</subject><subject>Toxicity testing</subject><issn>0250-474X</issn><issn>1998-3743</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNks1rFDEYxoModlu9e5IBL15mTSafcxFKqbVQqIc9iJeQzbzZpp1NajLTtf-9mW67dsWD5JCv3_Pw8vAg9I7gOSOYfsINxzWT7PucYIkVf4FmpG1VTSWjL9Fs932ADnO-xpi2DZWv0UFDRSNoK2fox-IKqjyM3X0VXWXC4K0JFlI5dg9XN4aV6StjB3_nBw954r75PBjrTeXDACtIya9NBb-GVLDqPFSFTPENeuVMn-Ht436EFl9OFydf64vLs_OT44va8lbYujNLSaABI4SVqhOYdEtMLRVgrCKKcSutUYI5IpnlzgkOHEu-VIRz5TA9Qp-3trfjcg2dhVDG6PXtNFO619F4vf8T_JVexTtNBcWSymLw8dEgxZ8j5EGvfbbQ9yZAHLMmVEimhKLtf6BMNlwwxgv64S_0Oo4plCAKRRQnRBD8hyoZg_bBxSnDyVQf06bMh4UkhZr_gyqrg7W3MYDz5X1PgLcCm2LOCdwuDoL11Bw9VUNP1dDb5hTJ--cx7gRPVSnA5RbYxH6AlG_6cQNJF_YmxM2ecf3MWFPJdSmZfiiZjk4_lYz-Bi5p2AQ</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Bibi, Y</creator><creator>Nisa, S</creator><creator>Zia, M</creator><creator>Waheed, A</creator><creator>Ahmed, S</creator><creator>Chaudhary, M</creator><general>Medknow Publications</general><general>Medknow Publications and Media Pvt. 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We have also investigated that crude stem extract of this plant also exhibits the antitumour as well as antifungal potential activities. Moreover, we have also studied that the crude extract inhibited Michigan Cancer Foundation-7 cell viability in a dose-dependent manner; the poor toxicity (1.6%) at 10 μg/ml to moderate toxicity (55.4%) at 100 μg/ml. The IC 50 values calculated were 90.9 μg/ml. The ethyl acetate and chloroform fractions at a concentration of 200 μg/ml showed ~100 and 97.4% inhibition against Michigan Cancer Foundation-7 cell line, respectively. The crude methanol extract also showed good antitumour (IC 50 125 ppm) activity, but weak antifungal activity. These findings reveal that the ethyl acetate and chloroform fractions of Pistacia integerrima are potent cytotoxic fractions, and could be an alternate candidate for the development of novel biologically active compounds.</abstract><cop>India</cop><pub>Medknow Publications</pub><pmid>23626397</pmid><doi>10.4103/0250-474X.107085</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anacardiaceae Antifungal activity Cell culture Cytotoxicity Drugs Fractionation In vitro Materia medica, Vegetable Microbiology Phytochemicals Plant extracts Product/Service Evaluations Short Communication Studies Testing Toxicity testing |
| title | The study of anticancer and antifungal activities of Pistacia integerrima extract In vitro |
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