OTUB1 modulates c-IAP1 stability to regulate signalling pathways

The cellular inhibitor of apoptosis (c‐IAP) proteins are E3 ubiquitin ligases that are critical regulators of tumour necrosis factor (TNF) receptor (TNFR)‐mediated signalling. Through their E3 ligase activity c‐IAP proteins promote ubiquitination of receptor‐interaction protein 1 (RIP1), NF‐κB‐induc...

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Veröffentlicht in:	The EMBO journal 2013-04, Vol.32 (8), p.1103-1114
Hauptverfasser:	Goncharov, Tatiana, Niessen, Kyle, de Almagro, Maria Cristina, Izrael-Tomasevic, Anita, Fedorova, Anna V, Varfolomeev, Eugene, Arnott, David, Deshayes, Kurt, Kirkpatrick, Donald S, Vucic, Domagoj
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Blood Vessels - embryology c-IAP1 Cell Line Cysteine Endopeptidases - metabolism Danio rerio DUB EMBO31 EMBO37 Enzymes Freshwater Gene expression Humans Hydrolysis Inhibitor of Apoptosis Proteins - metabolism Mitogen-Activated Protein Kinase Kinases - metabolism Molecular biology Mortality NF-kappa B - metabolism OTUB1 Proteins Signal Transduction TWEAK ubiquitin Ubiquitin - metabolism Zebrafish - embryology
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