Polyamidoamine dendrimer impairs mitochondrial oxidation in brain tissue

The potential nanocarrier polyamidoamine (PAMAM) generation 5 (G5-NH(2)) dendrimer has been shown to evoke lasting neuronal depolarization and cell death in a concentration-dependent manner. In this study we explored the early progression of G5-NH(2) action in brain tissue on neuronal and astroglial...

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Veröffentlicht in:	Journal of nanobiotechnology 2013-04, Vol.11 (1), p.9-9
Hauptverfasser:	Nyitrai, Gabriella, Héja, László, Jablonkai, István, Pál, Ildikó, Visy, Júlia, Kardos, Julianna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aqueous solutions Astrocytes - cytology Astrocytes - drug effects Astrocytes - pathology Brain Brain research Calcium Signaling Cell death Cell Membrane - chemistry Cell Survival - drug effects Dendrimers - chemistry Dendrimers - toxicity Experiments Fluorescent Dyes - analysis Fluorescent Dyes - metabolism Hippocampus - drug effects Hippocampus - metabolism Male Mitochondria Mitochondria - drug effects Mitochondria - pathology Neurons Neurons - cytology Neurons - drug effects Neurons - pathology Oxidation Oxidation-Reduction - drug effects Pharmacology Physiological aspects Plasma Polyamines - chemistry Polyamines - toxicity Rats Rats, Wistar Signal processing Software
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