Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series
Microsatellite instability (MSI) was suggested as a marker for good prognosis in colorectal cancer in 1993 and a systematic review from 2005 and a meta-analysis from 2010 support the initial observation. We here assess the prognostic impact and prevalence of MSI in different stages in a consecutive,...
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| Veröffentlicht in: | Annals of oncology 2013-05, Vol.24 (5), p.1274-1282 |
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| creator | Merok, M.A. Ahlquist, T. Røyrvik, E.C. Tufteland, K.F. Hektoen, M. Sjo, O.H. Mala, T. Svindland, A. Lothe, R.A. Nesbakken, A. |
| description | Microsatellite instability (MSI) was suggested as a marker for good prognosis in colorectal cancer in 1993 and a systematic review from 2005 and a meta-analysis from 2010 support the initial observation. We here assess the prognostic impact and prevalence of MSI in different stages in a consecutive, population-based series from a single hospital in Oslo, Norway.
Of 1274 patients, 952 underwent major resection of which 805 were included in analyses of MSI prevalence and 613 with complete resection in analyses of outcome. Formalin-fixed tumor tissue was used for PCR-based MSI analyses.
The overall prevalence of MSI was 14%, highest in females (19%) and in proximal colon cancer (29%). Five-year relapse-free survival (5-year RFS) was 67% and 55% (P = 0.030) in patients with MSI and MSS tumors, respectively, with the hazard ratio (HR) equal to 1.60 (P = 0.045) in multivariate analysis. The improved outcome was confined to stage II patients who had 5-year RFS of 74% and 56% respectively (P = 0.010), HR = 2.02 (P = 0.040).
Examination of 12 or more lymph nodes was significantly associated with proximal tumor location (P < 0.001).
MSI has an independent positive prognostic impact on stage II colorectal cancer patients after complete resection. |
| doi_str_mv | 10.1093/annonc/mds614 |
| format | Article |
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Of 1274 patients, 952 underwent major resection of which 805 were included in analyses of MSI prevalence and 613 with complete resection in analyses of outcome. Formalin-fixed tumor tissue was used for PCR-based MSI analyses.
The overall prevalence of MSI was 14%, highest in females (19%) and in proximal colon cancer (29%). Five-year relapse-free survival (5-year RFS) was 67% and 55% (P = 0.030) in patients with MSI and MSS tumors, respectively, with the hazard ratio (HR) equal to 1.60 (P = 0.045) in multivariate analysis. The improved outcome was confined to stage II patients who had 5-year RFS of 74% and 56% respectively (P = 0.010), HR = 2.02 (P = 0.040).
Examination of 12 or more lymph nodes was significantly associated with proximal tumor location (P < 0.001).
MSI has an independent positive prognostic impact on stage II colorectal cancer patients after complete resection.</description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/annonc/mds614</identifier><identifier>PMID: 23235802</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>adenocarcinoma ; Aged ; Aged, 80 and over ; Antineoplastic agents ; Biological and medical sciences ; Biomarkers, Tumor - genetics ; colorectal neoplasms ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - surgery ; Disease-Free Survival ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; lymph nodes ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Male ; Medical sciences ; Microsatellite Instability ; Middle Aged ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasm Recurrence, Local - genetics ; Neoplasm Staging ; Norway ; Original ; Pharmacology. Drug treatments ; prevalence ; Prognosis ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Annals of oncology, 2013-05, Vol.24 (5), p.1274-1282</ispartof><rights>2012 THE AUTHORS</rights><rights>2014 INIST-CNRS</rights><rights>The Author 2012. Published by Oxford University Press on behalf of the European Society for Medical Oncology. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-fbdfcd0c41c5b958d1e1af2a7cc45a45c4d3444dc7b82904f702440caee137a53</citedby><cites>FETCH-LOGICAL-c531t-fbdfcd0c41c5b958d1e1af2a7cc45a45c4d3444dc7b82904f702440caee137a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27292565$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23235802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Merok, M.A.</creatorcontrib><creatorcontrib>Ahlquist, T.</creatorcontrib><creatorcontrib>Røyrvik, E.C.</creatorcontrib><creatorcontrib>Tufteland, K.F.</creatorcontrib><creatorcontrib>Hektoen, M.</creatorcontrib><creatorcontrib>Sjo, O.H.</creatorcontrib><creatorcontrib>Mala, T.</creatorcontrib><creatorcontrib>Svindland, A.</creatorcontrib><creatorcontrib>Lothe, R.A.</creatorcontrib><creatorcontrib>Nesbakken, A.</creatorcontrib><title>Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description>Microsatellite instability (MSI) was suggested as a marker for good prognosis in colorectal cancer in 1993 and a systematic review from 2005 and a meta-analysis from 2010 support the initial observation. We here assess the prognostic impact and prevalence of MSI in different stages in a consecutive, population-based series from a single hospital in Oslo, Norway.
Of 1274 patients, 952 underwent major resection of which 805 were included in analyses of MSI prevalence and 613 with complete resection in analyses of outcome. Formalin-fixed tumor tissue was used for PCR-based MSI analyses.
The overall prevalence of MSI was 14%, highest in females (19%) and in proximal colon cancer (29%). Five-year relapse-free survival (5-year RFS) was 67% and 55% (P = 0.030) in patients with MSI and MSS tumors, respectively, with the hazard ratio (HR) equal to 1.60 (P = 0.045) in multivariate analysis. The improved outcome was confined to stage II patients who had 5-year RFS of 74% and 56% respectively (P = 0.010), HR = 2.02 (P = 0.040).
Examination of 12 or more lymph nodes was significantly associated with proximal tumor location (P < 0.001).
MSI has an independent positive prognostic impact on stage II colorectal cancer patients after complete resection.</description><subject>adenocarcinoma</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - genetics</subject><subject>colorectal neoplasms</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>lymph nodes</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microsatellite Instability</subject><subject>Middle Aged</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Staging</subject><subject>Norway</subject><subject>Original</subject><subject>Pharmacology. Drug treatments</subject><subject>prevalence</subject><subject>Prognosis</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kT2P1DAQhiME4paDkha5QaIgnL-yiSmQ0ImPlQ5ooLZmJ5M9o8QOtrPo_hC_Ey-7HFDQ2Jbm0TvjearqseAvBDfqArwPHi-mPq2FvlOtRLM2dce1uFutuJGqbhulz6oHKX3lnK-NNPerM6mkajouV9WPDw5jSJBpHF0m5nzKsHXlfcOuITFgc0guuz2xOYadDyk7ZG6aATMLnhV6R2yzYRjGEAkzjAzBI0UGQy4nhmkeqSRHSqXsgn95eC5jTmyIYSodRog7el5IX4jlV6-PIX6nnYPSgKKj9LC6N8CY6NHpPq--vH3z-fJ9ffXp3eby9VWNjRK5Hrb9gD1HLbDZmqbrBQkYJLSIugHdoO6V1rrHdttJw_XQcqk1RyASqoVGnVevjrnzsp2oR_I5wmjn6CaINzaAs_9WvLu2u7C3ai1NZ3QJeHYKiOHbQinbySUsywVPYUlWKCV4ZxppClof0YOAFGm4bSO4Pbi1R7f26LbwT_6e7Zb-LbMAT08AJIRxiMWDS3-4VhrZrA-fbI8clU3uHUWb0FFx1ruDQdsH958RfgLlnckt</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Merok, M.A.</creator><creator>Ahlquist, T.</creator><creator>Røyrvik, E.C.</creator><creator>Tufteland, K.F.</creator><creator>Hektoen, M.</creator><creator>Sjo, O.H.</creator><creator>Mala, T.</creator><creator>Svindland, A.</creator><creator>Lothe, R.A.</creator><creator>Nesbakken, A.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130501</creationdate><title>Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series</title><author>Merok, M.A. ; Ahlquist, T. ; Røyrvik, E.C. ; Tufteland, K.F. ; Hektoen, M. ; Sjo, O.H. ; Mala, T. ; Svindland, A. ; Lothe, R.A. ; Nesbakken, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-fbdfcd0c41c5b958d1e1af2a7cc45a45c4d3444dc7b82904f702440caee137a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>adenocarcinoma</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - genetics</topic><topic>colorectal neoplasms</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>lymph nodes</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microsatellite Instability</topic><topic>Middle Aged</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Staging</topic><topic>Norway</topic><topic>Original</topic><topic>Pharmacology. Drug treatments</topic><topic>prevalence</topic><topic>Prognosis</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Merok, M.A.</creatorcontrib><creatorcontrib>Ahlquist, T.</creatorcontrib><creatorcontrib>Røyrvik, E.C.</creatorcontrib><creatorcontrib>Tufteland, K.F.</creatorcontrib><creatorcontrib>Hektoen, M.</creatorcontrib><creatorcontrib>Sjo, O.H.</creatorcontrib><creatorcontrib>Mala, T.</creatorcontrib><creatorcontrib>Svindland, A.</creatorcontrib><creatorcontrib>Lothe, R.A.</creatorcontrib><creatorcontrib>Nesbakken, A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Merok, M.A.</au><au>Ahlquist, T.</au><au>Røyrvik, E.C.</au><au>Tufteland, K.F.</au><au>Hektoen, M.</au><au>Sjo, O.H.</au><au>Mala, T.</au><au>Svindland, A.</au><au>Lothe, R.A.</au><au>Nesbakken, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series</atitle><jtitle>Annals of oncology</jtitle><addtitle>Ann Oncol</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>24</volume><issue>5</issue><spage>1274</spage><epage>1282</epage><pages>1274-1282</pages><issn>0923-7534</issn><eissn>1569-8041</eissn><abstract>Microsatellite instability (MSI) was suggested as a marker for good prognosis in colorectal cancer in 1993 and a systematic review from 2005 and a meta-analysis from 2010 support the initial observation. We here assess the prognostic impact and prevalence of MSI in different stages in a consecutive, population-based series from a single hospital in Oslo, Norway.
Of 1274 patients, 952 underwent major resection of which 805 were included in analyses of MSI prevalence and 613 with complete resection in analyses of outcome. Formalin-fixed tumor tissue was used for PCR-based MSI analyses.
The overall prevalence of MSI was 14%, highest in females (19%) and in proximal colon cancer (29%). Five-year relapse-free survival (5-year RFS) was 67% and 55% (P = 0.030) in patients with MSI and MSS tumors, respectively, with the hazard ratio (HR) equal to 1.60 (P = 0.045) in multivariate analysis. The improved outcome was confined to stage II patients who had 5-year RFS of 74% and 56% respectively (P = 0.010), HR = 2.02 (P = 0.040).
Examination of 12 or more lymph nodes was significantly associated with proximal tumor location (P < 0.001).
MSI has an independent positive prognostic impact on stage II colorectal cancer patients after complete resection.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>23235802</pmid><doi>10.1093/annonc/mds614</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | adenocarcinoma Aged Aged, 80 and over Antineoplastic agents Biological and medical sciences Biomarkers, Tumor - genetics colorectal neoplasms Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - surgery Disease-Free Survival Female Gastroenterology. Liver. Pancreas. Abdomen Humans lymph nodes Lymph Nodes - pathology Lymphatic Metastasis Male Medical sciences Microsatellite Instability Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Recurrence, Local - genetics Neoplasm Staging Norway Original Pharmacology. Drug treatments prevalence Prognosis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series |
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