Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

Neurovascular dysfunction contributes to Alzheimer's disease (AD). Cerebrovascular abnormalities and blood–brain barrier (BBB) damage have been shown in AD. The BBB dysfunction can lead to leakage of potentially neurotoxic plasma components in brain that may contribute to neuronal injury. Peric...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain pathology (Zurich, Switzerland) Switzerland), 2013-05, Vol.23 (3), p.303-310
Hauptverfasser:	Sengillo, Jesse D., Winkler, Ethan A., Walker, Corey T., Sullivan, John S., Johnson, Mahlon, Zlokovic, Berislav V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - metabolism Blood Blood Proteins - metabolism Blood Vessels - pathology Blood-brain barrier Blood-Brain Barrier - pathology Cell Count Cerebral Cortex - pathology Cerebrovascular Circulation - physiology Female Fibrin - metabolism Fluorescent Antibody Technique Hippocampus - pathology Humans Image Processing, Computer-Assisted Immunoglobulin G - metabolism Male Middle Aged Myocytes, Smooth Muscle - pathology Neurology pericytes Pericytes - pathology Proteins Rodents
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!