Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers

Abstract Background Pharmacologic studies implicate a significant role of genes encoding the serotonin transporter ( SLC6A4 ) and the 5-HT3AB subunits HTR3A and HTR3B in nicotine dependence (ND). However, whether they are involved in ND remains largely unknown. Methods Here, we examined the impact o...

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Veröffentlicht in:	Drug and alcohol dependence 2013-05, Vol.129 (3), p.217-225
Hauptverfasser:	Yang, Zhongli, Seneviratne, Chamindi, Wang, Shaolin, Ma, Jennie Z, Payne, Thomas J, Wang, Jundong, Li, Ming D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African Americans - ethnology African Americans - genetics African and European American Association analysis Black American people Drug dependency Epistasis, Genetic - genetics Epistatic European Continental Ancestry Group - ethnology European Continental Ancestry Group - genetics Female Gene-by-gene interactions Genes Humans Male Middle Aged Nicotine dependence Polymorphism, Single Nucleotide - genetics Psychiatry Receptors, Serotonin, 5-HT3 - genetics Serotonin Serotonin Plasma Membrane Transport Proteins - genetics Serotonin receptor 3AB Serotonin transporter Smoking Tobacco Use Disorder - diagnosis Tobacco Use Disorder - ethnology Tobacco Use Disorder - genetics Variants
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