STIM1 Restores Coronary Endothelial Function in Type 1 Diabetic Mice

RATIONALE:The endoplasmic reticulum (ER) is a major intracellular Ca store in endothelial cells (ECs). The Ca concentration in the ER greatly contributes to the generation of Ca signals that regulate endothelial functions. Many proteins, including stromal interaction molecule 1/2 (STIM1/2), Orai1/2/...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation research 2012-10, Vol.111 (9), p.1166-1175
Hauptverfasser:	Estrada, Irene A, Donthamsetty, Reshma, Debski, Patryk, Zhou, Meng-Hua, Zhang, Shenyuan L, Yuan, Jason X.-J, Han, Wenlong, Makino, Ayako
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - metabolism Calcium Channels Calcium Signaling - physiology Cells, Cultured Coronary Vessels - metabolism Coronary Vessels - pathology Coronary Vessels - physiopathology Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - physiopathology Diabetes. Impaired glucose tolerance Disease Models, Animal Down-Regulation - drug effects Down-Regulation - physiology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endoplasmic Reticulum - metabolism Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty Acids, Nonesterified - pharmacology Fundamental and applied biological sciences. Psychology Male Medical sciences Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL RNA, Small Interfering - pharmacology Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Stromal Interaction Molecule 1 Up-Regulation - drug effects Up-Regulation - physiology Vertebrates: cardiovascular system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!