Association Between Maternal Mood and Oxytocin Response to Breastfeeding
Postpartum depression is associated with reduced breastfeeding duration. We previously hypothesized that shared neuroendocrine mechanisms underlie this association. We sought to measure the association between maternal mood and neuroendocrine response to breastfeeding. We conducted a longitudinal co...
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| Veröffentlicht in: | Journal of women's health (Larchmont, N.Y. 2002) N.Y. 2002), 2013-04, Vol.22 (4), p.352-361 |
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| creator | STUEBE, Alison M GREWEN, Karen MELTZER-BRODY, Samantha |
| description | Postpartum depression is associated with reduced breastfeeding duration. We previously hypothesized that shared neuroendocrine mechanisms underlie this association. We sought to measure the association between maternal mood and neuroendocrine response to breastfeeding.
We conducted a longitudinal cohort study of women recruited during pregnancy who intended to breastfeed. Baseline depression and anxiety history were assessed with a structured clinical interview. We measured mood symptoms using validated psychometric instruments, and we quantified affect and neuroendocrine responses to breastfeeding during laboratory visits at 2 and 8 weeks postpartum.
We recruited 52 women who intended to breastfeed, among whom 47 completed 8-week follow-up. Duration and intensity of breastfeeding through 8 weeks were similar among mothers with lower versus higher anxiety and depression scores. In the third trimester, oxytocin was inversely correlated with Edinburgh Postnatal Depression Scale (EPDS) score (p=0.03). We did not find differences in neuroendocrine profile during breastfeeding at 2 weeks postpartum. Among the 39 women who breastfed at 8 weeks postpartum, oxytocin area under the curve during breastfeeding was inversely correlated with maternal EPDS and STAI-State and STAI-Trait anxiety scores (all p≤0.01). Higher anxiety and depression scores was further associated with lower oxytocin (group p |
| doi_str_mv | 10.1089/jwh.2012.3768 |
| format | Article |
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We conducted a longitudinal cohort study of women recruited during pregnancy who intended to breastfeed. Baseline depression and anxiety history were assessed with a structured clinical interview. We measured mood symptoms using validated psychometric instruments, and we quantified affect and neuroendocrine responses to breastfeeding during laboratory visits at 2 and 8 weeks postpartum.
We recruited 52 women who intended to breastfeed, among whom 47 completed 8-week follow-up. Duration and intensity of breastfeeding through 8 weeks were similar among mothers with lower versus higher anxiety and depression scores. In the third trimester, oxytocin was inversely correlated with Edinburgh Postnatal Depression Scale (EPDS) score (p=0.03). We did not find differences in neuroendocrine profile during breastfeeding at 2 weeks postpartum. Among the 39 women who breastfed at 8 weeks postpartum, oxytocin area under the curve during breastfeeding was inversely correlated with maternal EPDS and STAI-State and STAI-Trait anxiety scores (all p≤0.01). Higher anxiety and depression scores was further associated with lower oxytocin (group p<0.05) during feeding. During feeding at both visits, higher anxiety and depression scores were also associated with more negative affect: mothers reported feeling less happy and more depressed, overwhelmed, and stressed during feeding than women with lower scores.
Symptoms of depression and anxiety were associated with differences in oxytocin response and affect during breastfeeding.</description><identifier>ISSN: 1540-9996</identifier><identifier>EISSN: 1931-843X</identifier><identifier>DOI: 10.1089/jwh.2012.3768</identifier><identifier>PMID: 23586800</identifier><language>eng</language><publisher>Larchmont, NY: Mary Ann Liebert</publisher><subject>Adult ; Adult and adolescent clinical studies ; Affect - physiology ; Anxiety ; Biological and medical sciences ; Breast Feeding - psychology ; Delivery. Postpartum. Lactation ; Depression ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Maternal, fetal and perinatal monitoring ; Medical sciences ; Mood disorders ; Original ; Oxytocin - blood ; Oxytocin - physiology ; Postpartum Period ; Pregnancy ; Pregnancy Trimester, Third ; Prospective Studies ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry</subject><ispartof>Journal of women's health (Larchmont, N.Y. 2002), 2013-04, Vol.22 (4), p.352-361</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright 2013, Mary Ann Liebert, Inc. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-f78a0d431f1f1aa4b9424718800a5616f4ec3aa4387fa4f5132f62a5fc3260053</citedby><cites>FETCH-LOGICAL-c483t-f78a0d431f1f1aa4b9424718800a5616f4ec3aa4387fa4f5132f62a5fc3260053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27379035$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23586800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STUEBE, Alison M</creatorcontrib><creatorcontrib>GREWEN, Karen</creatorcontrib><creatorcontrib>MELTZER-BRODY, Samantha</creatorcontrib><title>Association Between Maternal Mood and Oxytocin Response to Breastfeeding</title><title>Journal of women's health (Larchmont, N.Y. 2002)</title><addtitle>J Womens Health (Larchmt)</addtitle><description>Postpartum depression is associated with reduced breastfeeding duration. We previously hypothesized that shared neuroendocrine mechanisms underlie this association. We sought to measure the association between maternal mood and neuroendocrine response to breastfeeding.
We conducted a longitudinal cohort study of women recruited during pregnancy who intended to breastfeed. Baseline depression and anxiety history were assessed with a structured clinical interview. We measured mood symptoms using validated psychometric instruments, and we quantified affect and neuroendocrine responses to breastfeeding during laboratory visits at 2 and 8 weeks postpartum.
We recruited 52 women who intended to breastfeed, among whom 47 completed 8-week follow-up. Duration and intensity of breastfeeding through 8 weeks were similar among mothers with lower versus higher anxiety and depression scores. In the third trimester, oxytocin was inversely correlated with Edinburgh Postnatal Depression Scale (EPDS) score (p=0.03). We did not find differences in neuroendocrine profile during breastfeeding at 2 weeks postpartum. Among the 39 women who breastfed at 8 weeks postpartum, oxytocin area under the curve during breastfeeding was inversely correlated with maternal EPDS and STAI-State and STAI-Trait anxiety scores (all p≤0.01). Higher anxiety and depression scores was further associated with lower oxytocin (group p<0.05) during feeding. During feeding at both visits, higher anxiety and depression scores were also associated with more negative affect: mothers reported feeling less happy and more depressed, overwhelmed, and stressed during feeding than women with lower scores.
Symptoms of depression and anxiety were associated with differences in oxytocin response and affect during breastfeeding.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Affect - physiology</subject><subject>Anxiety</subject><subject>Biological and medical sciences</subject><subject>Breast Feeding - psychology</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Depression</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Maternal, fetal and perinatal monitoring</subject><subject>Medical sciences</subject><subject>Mood disorders</subject><subject>Original</subject><subject>Oxytocin - blood</subject><subject>Oxytocin - physiology</subject><subject>Postpartum Period</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Third</subject><subject>Prospective Studies</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><issn>1540-9996</issn><issn>1931-843X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtr3DAQh0VoybPHXIMvhVy8lTSyLV8CSWgekBAoKfQmJvIocfBKG0mbx39fLdmmLTqMmPn4zfAxti_4THDdf3t8eZhJLuQMulZvsG3Rg6i1gl-fyr9RvO77vt1iOyk9ci6l4HyTbUlodKs532YXxykFO2Ieg69OKL8Q-eoaM0WPU3UdwlChH6qb17dcMF_9oLQIPlGVQ3USCVN2RMPo7_fYZ4dToi_rust-nn2_Pb2or27OL0-Pr2qrNOTadRr5oEC48hDVXa-k6oQux2DTitYpslD6oDuHyjUCpGslNs6CbDlvYJcdveculndzGiz5HHEyizjOMb6ZgKP5f-LHB3Mfng20slMAJeBwHRDD05JSNvMxWZom9BSWyZSNWsq-lILW76iNIaVI7mON4GZl3xT7ZmXfrOwX_uDf2z7oP7oL8HUNYLI4uYjejukv10HXc2jgN4GEjdY</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>STUEBE, Alison M</creator><creator>GREWEN, Karen</creator><creator>MELTZER-BRODY, Samantha</creator><general>Mary Ann Liebert</general><general>Mary Ann Liebert, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130401</creationdate><title>Association Between Maternal Mood and Oxytocin Response to Breastfeeding</title><author>STUEBE, Alison M ; GREWEN, Karen ; MELTZER-BRODY, Samantha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-f78a0d431f1f1aa4b9424718800a5616f4ec3aa4387fa4f5132f62a5fc3260053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Affect - physiology</topic><topic>Anxiety</topic><topic>Biological and medical sciences</topic><topic>Breast Feeding - psychology</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Depression</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Maternal, fetal and perinatal monitoring</topic><topic>Medical sciences</topic><topic>Mood disorders</topic><topic>Original</topic><topic>Oxytocin - blood</topic><topic>Oxytocin - physiology</topic><topic>Postpartum Period</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Third</topic><topic>Prospective Studies</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STUEBE, Alison M</creatorcontrib><creatorcontrib>GREWEN, Karen</creatorcontrib><creatorcontrib>MELTZER-BRODY, Samantha</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of women's health (Larchmont, N.Y. 2002)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STUEBE, Alison M</au><au>GREWEN, Karen</au><au>MELTZER-BRODY, Samantha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Maternal Mood and Oxytocin Response to Breastfeeding</atitle><jtitle>Journal of women's health (Larchmont, N.Y. 2002)</jtitle><addtitle>J Womens Health (Larchmt)</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>22</volume><issue>4</issue><spage>352</spage><epage>361</epage><pages>352-361</pages><issn>1540-9996</issn><eissn>1931-843X</eissn><abstract>Postpartum depression is associated with reduced breastfeeding duration. We previously hypothesized that shared neuroendocrine mechanisms underlie this association. We sought to measure the association between maternal mood and neuroendocrine response to breastfeeding.
We conducted a longitudinal cohort study of women recruited during pregnancy who intended to breastfeed. Baseline depression and anxiety history were assessed with a structured clinical interview. We measured mood symptoms using validated psychometric instruments, and we quantified affect and neuroendocrine responses to breastfeeding during laboratory visits at 2 and 8 weeks postpartum.
We recruited 52 women who intended to breastfeed, among whom 47 completed 8-week follow-up. Duration and intensity of breastfeeding through 8 weeks were similar among mothers with lower versus higher anxiety and depression scores. In the third trimester, oxytocin was inversely correlated with Edinburgh Postnatal Depression Scale (EPDS) score (p=0.03). We did not find differences in neuroendocrine profile during breastfeeding at 2 weeks postpartum. Among the 39 women who breastfed at 8 weeks postpartum, oxytocin area under the curve during breastfeeding was inversely correlated with maternal EPDS and STAI-State and STAI-Trait anxiety scores (all p≤0.01). Higher anxiety and depression scores was further associated with lower oxytocin (group p<0.05) during feeding. During feeding at both visits, higher anxiety and depression scores were also associated with more negative affect: mothers reported feeling less happy and more depressed, overwhelmed, and stressed during feeding than women with lower scores.
Symptoms of depression and anxiety were associated with differences in oxytocin response and affect during breastfeeding.</abstract><cop>Larchmont, NY</cop><pub>Mary Ann Liebert</pub><pmid>23586800</pmid><doi>10.1089/jwh.2012.3768</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Affect - physiology Anxiety Biological and medical sciences Breast Feeding - psychology Delivery. Postpartum. Lactation Depression Female Gynecology. Andrology. Obstetrics Humans Maternal, fetal and perinatal monitoring Medical sciences Mood disorders Original Oxytocin - blood Oxytocin - physiology Postpartum Period Pregnancy Pregnancy Trimester, Third Prospective Studies Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | Association Between Maternal Mood and Oxytocin Response to Breastfeeding |
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