Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart

IGF-1 has been shown to protect myocardium against death in animal models of infarct and ischemia-reperfusion injury. In the present study, we investigated the role of the IGF-1-regulated protein kinase Akt in cardiac myocyte survival in vitro and in vivo. IGF-1 promoted survival of cultured cardiom...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2000-02, Vol.101 (6), p.660-667
Hauptverfasser:	FUJIO, Y, NGUYEN, T, WENCKER, D, KITSIS, R. N, WALSH, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiology. Vascular system Cell Survival - drug effects Cells, Cultured Coronary heart disease Heart Insulin-Like Growth Factor I - pharmacology Medical sciences Mice Mice, Inbred C57BL Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardium - metabolism Myocardium - pathology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Signal Transduction - drug effects
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