IL-21 promotes the expansion of CD27+ CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells

Adoptive cell transfer of tumor infiltrating lymphocytes has shown clinical efficacy in the treatment of melanoma and is now also being explored in other tumor types. Generation of sufficient numbers of effector T cells requires extensive ex vivo expansion, often at the cost of T cell differentiatio...

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Veröffentlicht in:	Journal of translational medicine 2013-02, Vol.11 (1), p.37-37, Article 37
Hauptverfasser:	Santegoets, Saskia J A M, Turksma, Annelies W, Suhoski, Megan M, Stam, Anita G M, Albelda, Steve M, Hooijberg, Erik, Scheper, Rik J, van den Eertwegh, Alfons J M, Gerritsen, Winald R, Powell, Jr, Daniel J, June, Carl H, de Gruijl, Tanja D
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biopsy Cancer Care and treatment CD28 Antigens - metabolism CD8-Positive T-Lymphocytes - cytology Cell differentiation Cell Proliferation Comparative analysis Cytokines Cytokines - metabolism Cytotoxicity Diagnosis Enzyme-Linked Immunosorbent Assay Expansion Flow Cytometry Genotype & phenotype Health aspects Humans Immune system Interleukins - metabolism K562 Cells Lung cancer, Non-small cell Lymphocytes Lymphocytes, Tumor-Infiltrating - cytology Medical research Melanoma Neoplasms - metabolism Ovarian cancer Phenotype Physiological aspects Receptors, IgG - metabolism Risk factors T cells T-Lymphocytes, Regulatory - cytology Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism
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