Human single-stranded DNA binding proteins are essential for maintaining genomic stability

The double-stranded conformation of cellular DNA is a central aspect of DNA stabilisation and protection. The helix preserves the genetic code against chemical and enzymatic degradation, metabolic activation, and formation of secondary structures. However, there are various instances where single-st...

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Veröffentlicht in:	BMC molecular biology 2013-04, Vol.14 (1), p.9-9, Article 9
Hauptverfasser:	Ashton, Nicholas W, Bolderson, Emma, Cubeddu, Liza, O'Byrne, Kenneth J, Richard, Derek J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cell activation Cell Cycle Colleges & universities Councils Deoxyribonucleic acid DNA DNA binding proteins DNA damage DNA Repair DNA Replication DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enzymes Genetic transcription Genetics Genomes Genomic Instability Genomics Humans Kinases Oligonucleotides - genetics Oligonucleotides - metabolism Polypeptides Protein binding Proteins Review Telomerase Telomeres
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