Synthetic immunotherapy induces HIV virus specific Th1 cytotoxic response and death of an HIV-1 infected human cell line through classic complement activation

BACKGROUND: This manuscript describes the development of a novel synthetic immunotherapy (HIV-v) composed of four multi-epitope polypeptides targeting conserved regions in the Nef, Rev, Vif and Vpr viral proteins. Immunogenicity and cytotoxicity of HIV-v are discussed. METHODS: Short conserved T-cel...

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Veröffentlicht in:	Virology journal 2013-04, Vol.10 (1), p.107-107, Article 107
Hauptverfasser:	Pleguezuelos, Olga, Stoloff, Gregory A, Caparrós-Wanderley, Wilson
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Animals antibodies antigens Antigens, CD - analysis Antiviral agents Care and treatment CD8-positive T-lymphocytes Cell Death complement Complement Activation computer simulation cytotoxicity death enzyme-linked immunosorbent assay Epitopes, T-Lymphocyte - immunology Female Flow Cytometry Genetic aspects genetically modified organisms HIV HIV (Viruses) HIV Antibodies - blood HIV infection HIV infections HIV-1 - immunology HLA-A2 Antigen - immunology human cell lines Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immune response immunization immunogenicity immunoglobulin G Immunotherapy Immunotherapy - methods interferon-gamma Interferon-gamma - secretion Male Mice Mice, Inbred C57BL Mice, Transgenic Patient outcomes Physiological aspects polypeptides Prevention Proteins proteome splenocytes Th1 Cells - immunology Vaccines Viral proteins Viral Proteins - immunology viruses
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