Oral squamous cell carcinoma in relation to field precancerisation: pathobiology
Squamous cell carcinoma of the oral cavity evolves within a field of precancerized oral epithelium containing keratinocytes at different stages of transformation. Following acquisition of additional genetic alterations, these precancerous keratinocytes may become cancerous.Persons with apparently su...
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| Veröffentlicht in: | Cancer Cell International 2013-04, Vol.13 (1), p.31-31 |
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| creator | Feller, Liviu L Khammissa, Razia Rag Kramer, Beverly B Lemmer, Johan J |
| description | Squamous cell carcinoma of the oral cavity evolves within a field of precancerized oral epithelium containing keratinocytes at different stages of transformation. Following acquisition of additional genetic alterations, these precancerous keratinocytes may become cancerous.Persons with apparently successfully treated oral squamous cell carcinoma are at high risk of developing a new carcinoma at, or close to the site of the treated tumour. This second carcinoma may have developed either from malignant keratinocytes left behind at surgery (recurrence), or from transformed keratinocytes within the field of precancerized epithelium from which the primary carcinoma had arisen (new carcinoma).The cells of the new carcinoma may have genetic changes in common with the cells of the original carcinoma because both are descended from a proliferating monoclone within the precancerized field; but if the new cancer originates from a different clone, it may have a dissimilar genetic profile even if the original and the new carcinoma are closely contiguous.The purpose of this article is to review the pathobiology of oral squamous cell carcinoma in relation to fields of precancerised oral epithelium. |
| doi_str_mv | 10.1186/1475-2867-13-31 |
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This second carcinoma may have developed either from malignant keratinocytes left behind at surgery (recurrence), or from transformed keratinocytes within the field of precancerized epithelium from which the primary carcinoma had arisen (new carcinoma).The cells of the new carcinoma may have genetic changes in common with the cells of the original carcinoma because both are descended from a proliferating monoclone within the precancerized field; but if the new cancer originates from a different clone, it may have a dissimilar genetic profile even if the original and the new carcinoma are closely contiguous.The purpose of this article is to review the pathobiology of oral squamous cell carcinoma in relation to fields of precancerised oral epithelium.</description><identifier>ISSN: 1475-2867</identifier><identifier>EISSN: 1475-2867</identifier><identifier>DOI: 10.1186/1475-2867-13-31</identifier><identifier>PMID: 23552362</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Acquisitions & mergers ; Apoptosis ; Cancer ; Cell division ; Colleges & universities ; Development and progression ; Genetic engineering ; Genotype & phenotype ; Health sciences ; Population ; Review ; Squamous cell carcinoma ; Stem cells</subject><ispartof>Cancer Cell International, 2013-04, Vol.13 (1), p.31-31</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Feller et al.; licensee BioMed Central Ltd. 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| subjects | Acquisitions & mergers Apoptosis Cancer Cell division Colleges & universities Development and progression Genetic engineering Genotype & phenotype Health sciences Population Review Squamous cell carcinoma Stem cells |
| title | Oral squamous cell carcinoma in relation to field precancerisation: pathobiology |
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