Nuclear Positioning
The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet during cell division, migration, and differentiation, it frequently moves to an asymmetric position aligned with cell function. We consider the toolbox of proteins that move and anchor the nucleus within the...
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| Veröffentlicht in: | Cell 2013-03, Vol.152 (6), p.1376-1389 |
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| container_title | Cell |
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| creator | Gundersen, Gregg G. Worman, Howard J. |
| description | The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet during cell division, migration, and differentiation, it frequently moves to an asymmetric position aligned with cell function. We consider the toolbox of proteins that move and anchor the nucleus within the cell and how forces generated by the cytoskeleton are coupled to the nucleus to move it. The significance of proper nuclear positioning is underscored by numerous diseases resulting from genetic alterations in the toolbox proteins. Finally, we discuss how nuclear position may influence cellular organization and signaling pathways. |
| doi_str_mv | 10.1016/j.cell.2013.02.031 |
| format | Article |
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Finally, we discuss how nuclear position may influence cellular organization and signaling pathways.</description><subject>Animals</subject><subject>Biomechanical Phenomena</subject><subject>cell division</subject><subject>Cell Nucleus - chemistry</subject><subject>Cell Nucleus - metabolism</subject><subject>Cells - pathology</subject><subject>cytoskeleton</subject><subject>Cytoskeleton - metabolism</subject><subject>Humans</subject><subject>Microtubules - metabolism</subject><subject>proteins</subject><subject>signal transduction</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9LwzAYhoMobk5P3jyIRy-tX5K2SUAEGf4CUQ96Dl3ybWZ07Uzagf-9KZtDL0oOOeR533zfQ8gJhZQCLS7mqcGqShlQngJLgdMdMqSgRJJRwXbJEECxRBYiG5CDEOYAIPM83ycDxjMlVZYNyfFTZyos_dlLE1zrmtrVs0OyNy2rgEebe0Tebm9ex_fJ4_Pdw_j6MTE5F22izJRyYeInaCQgU3xiIc8Ai3yCVjGcMOQCS7CcWeAoFRgshFVWGGpR8BG5Wvcuu8kCrcG69WWll94tSv-pm9Lp3y-1e9ezZqV5weLJYsH5psA3Hx2GVi9c6J2UNTZd0CxuTIFLRv9FKadC5lAUMqJsjRrfhOBxup2Igu7F67nuk7oXr4HpKD6GTn_uso18m47A5RrAaHTl0OtgHNYGrfNoWm0b91f_F7W1k2E</recordid><startdate>20130314</startdate><enddate>20130314</enddate><creator>Gundersen, Gregg G.</creator><creator>Worman, Howard J.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20130314</creationdate><title>Nuclear Positioning</title><author>Gundersen, Gregg G. ; Worman, Howard J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-9cf137c009ec80e293bd0540e65bed92eb2e37ea0d32d03e890ce67d9d7c1de73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Biomechanical Phenomena</topic><topic>cell division</topic><topic>Cell Nucleus - chemistry</topic><topic>Cell Nucleus - metabolism</topic><topic>Cells - pathology</topic><topic>cytoskeleton</topic><topic>Cytoskeleton - metabolism</topic><topic>Humans</topic><topic>Microtubules - metabolism</topic><topic>proteins</topic><topic>signal transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gundersen, Gregg G.</creatorcontrib><creatorcontrib>Worman, Howard J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gundersen, Gregg G.</au><au>Worman, Howard J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nuclear Positioning</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2013-03-14</date><risdate>2013</risdate><volume>152</volume><issue>6</issue><spage>1376</spage><epage>1389</epage><pages>1376-1389</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>The nucleus is the largest organelle and is commonly depicted in the center of the cell. 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| ispartof | Cell, 2013-03, Vol.152 (6), p.1376-1389 |
| issn | 0092-8674 1097-4172 |
| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biomechanical Phenomena cell division Cell Nucleus - chemistry Cell Nucleus - metabolism Cells - pathology cytoskeleton Cytoskeleton - metabolism Humans Microtubules - metabolism proteins signal transduction |
| title | Nuclear Positioning |
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