Virus-Specific CD4+ Memory-Phenotype T Cells Are Abundant in Unexposed Adults

Although T cell memory is generally thought to require direct antigen exposure, we found an abundance of memory-phenotype cells (20%–90%, averaging over 50%) of CD4+ T cells specific to viral antigens in adults who had never been infected. These cells express the appropriate memory markers and genes...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2013-02, Vol.38 (2), p.373-383
Hauptverfasser:	Su, Laura F., Kidd, Brian A., Han, Arnold, Kotzin, Jonathan J., Davis, Mark M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence Antigens Binding sites Blood & organ donations CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology Cell Proliferation Child Clone Cells Cloning Cytokines Cytomegalovirus Gene expression Genotype & phenotype HIV Infections - immunology HIV Infections - pathology HIV Infections - virology HIV-1 - immunology Human immunodeficiency virus 1 Humans Hypothesis testing Immunologic Memory Immunophenotyping Infant, Newborn Infectious diseases Influenza A Virus, H1N1 Subtype - immunology Influenza Vaccines - immunology Influenza, Human - immunology Influenza, Human - pathology Influenza, Human - prevention & control Influenza, Human - virology Molecular Sequence Data Peptides Peptides - immunology Phenotype Proteins Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology T cell receptors T-Cell Antigen Receptor Specificity Vaccination
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