Neutral Polymeric Micelles for RNA Delivery

RNA interference (RNAi) drugs have significant therapeutic potential, but delivery systems with appropriate efficacy and toxicity profiles are still needed. Here, we describe a neutral, ampholytic polymeric delivery system based on conjugatable diblock polymer micelles. The diblock copolymer contain...

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Veröffentlicht in:	Bioconjugate chemistry 2013-03, Vol.24 (3), p.398-407
Hauptverfasser:	Lundy, Brittany B, Convertine, Anthony, Miteva, Martina, Stayton, Patrick S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatibility Copolymers Cytotoxicity Erythrocytes - drug effects Gene Transfer Techniques HeLa Cells Humans Hydrophobic surfaces Micelles Molecular weight Polymerization Polymers - administration & dosage Polymers - chemistry Ribonucleic acid RNA RNA, Small Interfering - administration & dosage RNA, Small Interfering - chemistry RNA, Small Interfering - genetics
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