Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?

Abstract Background Genome-wide association studies have identified at least 15 independent common genetic variants associated with colorectal cancer (CRC) risk. The aim of this study was to investigate whether 11 of these variants are associated with CRC risk for carriers of germline mutations in D...

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Veröffentlicht in:	European journal of cancer (1990) 2013-05, Vol.49 (7), p.1578-1587
Hauptverfasser:	Win, Aung Ko, Hopper, John L, Buchanan, Daniel D, Young, Joanne P, Tenesa, Albert, Dowty, James G, Giles, Graham G, Goldblatt, Jack, Winship, Ingrid, Boussioutas, Alex, Young, Graeme P, Parry, Susan, Baron, John A, Duggan, David, Gallinger, Steven, Newcomb, Polly A, Haile, Robert W, Marchand, Loïc Le, Lindor, Noralane M, Jenkins, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adenosine Triphosphatases - genetics Adult Age Alleles Biological and medical sciences Colorectal cancer Colorectal Neoplasms - genetics DNA Mismatch Repair - genetics DNA Repair Enzymes - genetics DNA-Binding Proteins - genetics Family Health Female Gene Frequency Genetic Predisposition to Disease - genetics Genetic variant Genotype Germ-Line Mutation Hematology, Oncology and Palliative Medicine Heterozygote Humans Lynch syndrome Male Medical sciences Middle Aged Mismatch repair Mismatch Repair Endonuclease PMS2 Multiple tumors. Solid tumors. Tumors in childhood (general aspects) MutL Protein Homolog 1 MutS Homolog 2 Protein - genetics Nuclear Proteins - genetics Pharmacology. Drug treatments Polymorphism, Single Nucleotide Proportional Hazards Models Risk Assessment - statistics & numerical data Risk Factors Tumors
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