Etravirine in CSF is highly protein bound

Etravirine has high affinity for plasma drug-binding proteins, such as albumin and α1-acid glycoprotein, which limits the amount of unbound etravirine available to enter the CNS. The objective of this study was to compare total and unbound etravirine concentrations in CSF with plasma concentrations...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2013-05, Vol.68 (5), p.1161-1168
Hauptverfasser:	Nguyen, Anh, Rossi, Steven, Croteau, David, Best, Brookie M, Clifford, David, Collier, Ann C, Gelman, Benjamin, Marra, Christina, McArthur, Justin, McCutchan, J Allen, Morgello, Susan, Simpson, David, Ellis, Ronald J, Grant, Igor, Capparelli, Edmund, Letendre, Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-HIV Agents - analysis Anti-HIV Agents - metabolism Anti-HIV Agents - pharmacokinetics Cerebrospinal Fluid - chemistry Chromatography Chromatography, High Pressure Liquid Cohort Studies Drug therapy Female Glycoproteins HIV HIV Infections - drug therapy Human immunodeficiency virus Humans Inhibitory Concentration 50 Isotope Labeling Male Mass spectrometry Middle Aged Original Research Plasma Plasma - chemistry Protein Binding Proteins Proteins - metabolism Pyridazines - analysis Pyridazines - metabolism Pyridazines - pharmacokinetics Tandem Mass Spectrometry Ultracentrifugation
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