Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X‑ray Structure by Racemic Protein Crystallography

Efficient total synthesis of insulin is important to enable the application of medicinal chemistry to the optimization of the properties of this important protein molecule. Recently we described “ester insulin”a novel form of insulin in which the function of the 35 residue C-peptide of proinsulin i...

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