Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes
To examine whether the initial benefit of weight loss on obstructive sleep apnea (OSA) severity at 1 year is maintained at 4 years. Randomized controlled trial with follow-up at 1, 2, and 4 years. 4 Look AHEAD clinical centers. Two hundred sixty-four obese adults with type 2 diabetes and OSA. Intens...
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| Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2013-05, Vol.36 (5), p.641-649 |
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| creator | Kuna, Samuel T Reboussin, David M Borradaile, Kelley E Sanders, Mark H Millman, Richard P Zammit, Gary Newman, Anne B Wadden, Thomas A Jakicic, John M Wing, Rena R Pi-Sunyer, F Xavier Foster, Gary D |
| description | To examine whether the initial benefit of weight loss on obstructive sleep apnea (OSA) severity at 1 year is maintained at 4 years.
Randomized controlled trial with follow-up at 1, 2, and 4 years.
4 Look AHEAD clinical centers.
Two hundred sixty-four obese adults with type 2 diabetes and OSA.
Intensive lifestyle intervention with a behavioral weight loss program or diabetes support and education.
Change in apnea-hypopnea index on polysomnogram.
The intensive lifestyle intervention group's mean weight loss was 10.7 ± 0.7 (standard error), 7.4 ± 0.7, and 5.2 ± 0.7 kg at 1, 2, and 4 years respectively, compared to a less than 1-kg weight loss for the control group at each time (P < 0.001). Apnea-hypopnea index difference between groups was 9.7 ± 2.0, 8.0 ± 2.0, and 7.7 ± 2.3 events/h at 1, 2 and 4 years respectively (P < 0.001). Change in apnea-hypopnea index over time was related to the amount of weight loss (P < 0.0001) and intervention, independent of weight loss (P = 0.001). Remission of OSA at 4 years was 5 times more common with intensive lifestyle intervention (20.7%) than diabetes support and education (3.6%).
Among obese adults with type 2 diabetes and OSA, intensive lifestyle intervention produced greater reductions in weight and apnea-hypopnea index over a 4 year period than did diabetes support and education. Beneficial effects of intensive lifestyle intervention on apneahypopnea index at 1 year persisted at 4 years, despite an almost 50% weight regain. Effect of intensive lifestyle intervention on apnea-hypopnea index was largely, but not entirely, due to weight loss. |
| doi_str_mv | 10.5665/sleep.2618 |
| format | Article |
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Randomized controlled trial with follow-up at 1, 2, and 4 years.
4 Look AHEAD clinical centers.
Two hundred sixty-four obese adults with type 2 diabetes and OSA.
Intensive lifestyle intervention with a behavioral weight loss program or diabetes support and education.
Change in apnea-hypopnea index on polysomnogram.
The intensive lifestyle intervention group's mean weight loss was 10.7 ± 0.7 (standard error), 7.4 ± 0.7, and 5.2 ± 0.7 kg at 1, 2, and 4 years respectively, compared to a less than 1-kg weight loss for the control group at each time (P < 0.001). Apnea-hypopnea index difference between groups was 9.7 ± 2.0, 8.0 ± 2.0, and 7.7 ± 2.3 events/h at 1, 2 and 4 years respectively (P < 0.001). Change in apnea-hypopnea index over time was related to the amount of weight loss (P < 0.0001) and intervention, independent of weight loss (P = 0.001). Remission of OSA at 4 years was 5 times more common with intensive lifestyle intervention (20.7%) than diabetes support and education (3.6%).
Among obese adults with type 2 diabetes and OSA, intensive lifestyle intervention produced greater reductions in weight and apnea-hypopnea index over a 4 year period than did diabetes support and education. Beneficial effects of intensive lifestyle intervention on apneahypopnea index at 1 year persisted at 4 years, despite an almost 50% weight regain. Effect of intensive lifestyle intervention on apnea-hypopnea index was largely, but not entirely, due to weight loss.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.5665/sleep.2618</identifier><identifier>PMID: 23633746</identifier><language>eng</language><publisher>United States: Associated Professional Sleep Societies, LLC</publisher><subject>Adult ; Aged ; Body Mass Index ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - therapy ; Effect of Weight Loss on OSA in Obese Patients with Type 2 Diabetes ; Feeding Behavior ; Female ; Follow-Up Studies ; Humans ; Life Style ; Male ; Middle Aged ; Obesity - complications ; Obesity - therapy ; Patient Education as Topic ; Polysomnography ; Severity of Illness Index ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - therapy ; Time Factors ; Treatment Outcome ; Weight Loss</subject><ispartof>Sleep (New York, N.Y.), 2013-05, Vol.36 (5), p.641-649</ispartof><rights>2013 Associated Professional Sleep Societies, LLC. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-76222d1ac659a0b88a77df738bf9e8d6e019f3fbd8aee06d6eee4067df1176e3</citedby><cites>FETCH-LOGICAL-c378t-76222d1ac659a0b88a77df738bf9e8d6e019f3fbd8aee06d6eee4067df1176e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23633746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuna, Samuel T</creatorcontrib><creatorcontrib>Reboussin, David M</creatorcontrib><creatorcontrib>Borradaile, Kelley E</creatorcontrib><creatorcontrib>Sanders, Mark H</creatorcontrib><creatorcontrib>Millman, Richard P</creatorcontrib><creatorcontrib>Zammit, Gary</creatorcontrib><creatorcontrib>Newman, Anne B</creatorcontrib><creatorcontrib>Wadden, Thomas A</creatorcontrib><creatorcontrib>Jakicic, John M</creatorcontrib><creatorcontrib>Wing, Rena R</creatorcontrib><creatorcontrib>Pi-Sunyer, F Xavier</creatorcontrib><creatorcontrib>Foster, Gary D</creatorcontrib><creatorcontrib>Sleep AHEAD Research Group of the Look AHEAD Research Group</creatorcontrib><title>Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes</title><title>Sleep (New York, N.Y.)</title><addtitle>Sleep</addtitle><description>To examine whether the initial benefit of weight loss on obstructive sleep apnea (OSA) severity at 1 year is maintained at 4 years.
Randomized controlled trial with follow-up at 1, 2, and 4 years.
4 Look AHEAD clinical centers.
Two hundred sixty-four obese adults with type 2 diabetes and OSA.
Intensive lifestyle intervention with a behavioral weight loss program or diabetes support and education.
Change in apnea-hypopnea index on polysomnogram.
The intensive lifestyle intervention group's mean weight loss was 10.7 ± 0.7 (standard error), 7.4 ± 0.7, and 5.2 ± 0.7 kg at 1, 2, and 4 years respectively, compared to a less than 1-kg weight loss for the control group at each time (P < 0.001). Apnea-hypopnea index difference between groups was 9.7 ± 2.0, 8.0 ± 2.0, and 7.7 ± 2.3 events/h at 1, 2 and 4 years respectively (P < 0.001). Change in apnea-hypopnea index over time was related to the amount of weight loss (P < 0.0001) and intervention, independent of weight loss (P = 0.001). Remission of OSA at 4 years was 5 times more common with intensive lifestyle intervention (20.7%) than diabetes support and education (3.6%).
Among obese adults with type 2 diabetes and OSA, intensive lifestyle intervention produced greater reductions in weight and apnea-hypopnea index over a 4 year period than did diabetes support and education. Beneficial effects of intensive lifestyle intervention on apneahypopnea index at 1 year persisted at 4 years, despite an almost 50% weight regain. Effect of intensive lifestyle intervention on apnea-hypopnea index was largely, but not entirely, due to weight loss.</description><subject>Adult</subject><subject>Aged</subject><subject>Body Mass Index</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - therapy</subject><subject>Effect of Weight Loss on OSA in Obese Patients with Type 2 Diabetes</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Life Style</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - complications</subject><subject>Obesity - therapy</subject><subject>Patient Education as Topic</subject><subject>Polysomnography</subject><subject>Severity of Illness Index</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Weight Loss</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1LAzEQhoMotlYv_gDJUYTVZLObZC-CFL-g4KX3kN2dtCnbzZqkLf33bj8sehpm5uGdl3kRuqXkMec8fwoNQPeYcirP0JDmOUkKSopzNCSU00RSkg_QVQgL0vdZwS7RIGWcMZHxIVpMXDtLIvglBmOgitgZvAE7m0fcuBCwa7ErQ_SrKto14P0trLsWNA6wBm_jFtsdAwFwp6OFNga8sXGO47YDnOLa6hIihGt0YXQT4OZYR2j69jodfySTr_fP8cskqZiQMRE8TdOa6ornhSallFqI2ggmS1OArDkQWhhmylpqAML7AUBGeM9QKjiwEXo-yHarcgl11fvxulGdt0vtt8ppq_5vWjtXM7dWjKeZpLIXuD8KePe9ghDV0oYKmka34FZBUZYJIQuSsR59OKCV73_lwZzOUKJ22aj9v9Qumx6--2vshP6GwX4AbjmONg</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Kuna, Samuel T</creator><creator>Reboussin, David M</creator><creator>Borradaile, Kelley E</creator><creator>Sanders, Mark H</creator><creator>Millman, Richard P</creator><creator>Zammit, Gary</creator><creator>Newman, Anne B</creator><creator>Wadden, Thomas A</creator><creator>Jakicic, John M</creator><creator>Wing, Rena R</creator><creator>Pi-Sunyer, F Xavier</creator><creator>Foster, Gary D</creator><general>Associated Professional Sleep Societies, LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130501</creationdate><title>Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes</title><author>Kuna, Samuel T ; Reboussin, David M ; Borradaile, Kelley E ; Sanders, Mark H ; Millman, Richard P ; Zammit, Gary ; Newman, Anne B ; Wadden, Thomas A ; Jakicic, John M ; Wing, Rena R ; Pi-Sunyer, F Xavier ; Foster, Gary D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-76222d1ac659a0b88a77df738bf9e8d6e019f3fbd8aee06d6eee4067df1176e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Body Mass Index</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - therapy</topic><topic>Effect of Weight Loss on OSA in Obese Patients with Type 2 Diabetes</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Life Style</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - complications</topic><topic>Obesity - therapy</topic><topic>Patient Education as Topic</topic><topic>Polysomnography</topic><topic>Severity of Illness Index</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - therapy</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuna, Samuel T</creatorcontrib><creatorcontrib>Reboussin, David M</creatorcontrib><creatorcontrib>Borradaile, Kelley E</creatorcontrib><creatorcontrib>Sanders, Mark H</creatorcontrib><creatorcontrib>Millman, Richard P</creatorcontrib><creatorcontrib>Zammit, Gary</creatorcontrib><creatorcontrib>Newman, Anne B</creatorcontrib><creatorcontrib>Wadden, Thomas A</creatorcontrib><creatorcontrib>Jakicic, John M</creatorcontrib><creatorcontrib>Wing, Rena R</creatorcontrib><creatorcontrib>Pi-Sunyer, F Xavier</creatorcontrib><creatorcontrib>Foster, Gary D</creatorcontrib><creatorcontrib>Sleep AHEAD Research Group of the Look AHEAD Research Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuna, Samuel T</au><au>Reboussin, David M</au><au>Borradaile, Kelley E</au><au>Sanders, Mark H</au><au>Millman, Richard P</au><au>Zammit, Gary</au><au>Newman, Anne B</au><au>Wadden, Thomas A</au><au>Jakicic, John M</au><au>Wing, Rena R</au><au>Pi-Sunyer, F Xavier</au><au>Foster, Gary D</au><aucorp>Sleep AHEAD Research Group of the Look AHEAD Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><addtitle>Sleep</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>36</volume><issue>5</issue><spage>641</spage><epage>649</epage><pages>641-649</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>To examine whether the initial benefit of weight loss on obstructive sleep apnea (OSA) severity at 1 year is maintained at 4 years.
Randomized controlled trial with follow-up at 1, 2, and 4 years.
4 Look AHEAD clinical centers.
Two hundred sixty-four obese adults with type 2 diabetes and OSA.
Intensive lifestyle intervention with a behavioral weight loss program or diabetes support and education.
Change in apnea-hypopnea index on polysomnogram.
The intensive lifestyle intervention group's mean weight loss was 10.7 ± 0.7 (standard error), 7.4 ± 0.7, and 5.2 ± 0.7 kg at 1, 2, and 4 years respectively, compared to a less than 1-kg weight loss for the control group at each time (P < 0.001). Apnea-hypopnea index difference between groups was 9.7 ± 2.0, 8.0 ± 2.0, and 7.7 ± 2.3 events/h at 1, 2 and 4 years respectively (P < 0.001). Change in apnea-hypopnea index over time was related to the amount of weight loss (P < 0.0001) and intervention, independent of weight loss (P = 0.001). Remission of OSA at 4 years was 5 times more common with intensive lifestyle intervention (20.7%) than diabetes support and education (3.6%).
Among obese adults with type 2 diabetes and OSA, intensive lifestyle intervention produced greater reductions in weight and apnea-hypopnea index over a 4 year period than did diabetes support and education. Beneficial effects of intensive lifestyle intervention on apneahypopnea index at 1 year persisted at 4 years, despite an almost 50% weight regain. Effect of intensive lifestyle intervention on apnea-hypopnea index was largely, but not entirely, due to weight loss.</abstract><cop>United States</cop><pub>Associated Professional Sleep Societies, LLC</pub><pmid>23633746</pmid><doi>10.5665/sleep.2618</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0161-8105 |
| ispartof | Sleep (New York, N.Y.), 2013-05, Vol.36 (5), p.641-649 |
| issn | 0161-8105 1550-9109 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Body Mass Index Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - therapy Effect of Weight Loss on OSA in Obese Patients with Type 2 Diabetes Feeding Behavior Female Follow-Up Studies Humans Life Style Male Middle Aged Obesity - complications Obesity - therapy Patient Education as Topic Polysomnography Severity of Illness Index Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - therapy Time Factors Treatment Outcome Weight Loss |
| title | Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes |
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