Discovery and Structure–Activity Relationships of Pyrrolone Antimalarials

In the pursuit of new antimalarial leads, a phenotypic screening of various commercially sourced compound libraries was undertaken by the World Health Organisation Programme for Research and Training in Tropical Diseases (WHO-TDR). We report here the detailed characterization of one of the hits from...

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Veröffentlicht in:	Journal of medicinal chemistry 2013-04, Vol.56 (7), p.2975-2990
Hauptverfasser:	Murugesan, Dinakaran, Mital, Alka, Kaiser, Marcel, Shackleford, David M, Morizzi, Julia, Katneni, Kasiram, Campbell, Michael, Hudson, Alan, Charman, Susan A, Yeates, Clive, Gilbert, Ian H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - chemistry Antimalarials - pharmacology Cell Line Drug Discovery Magnetic Resonance Spectroscopy Mass Spectrometry Plasmodium falciparum Plasmodium falciparum - drug effects Pyrroles - chemistry Pyrroles - pharmacology Rats Structure-Activity Relationship
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