Metabolome Response to Glucose in the β-Cell Line INS-1 832/13

Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells is triggered by metabolism of the sugar to increase ATP/ADP ratio that blocks the KATP channel leading to membrane depolarization and insulin exocytosis. Other metabolic pathways believed to augment insulin secretion have yet to be...

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Veröffentlicht in:	The Journal of biological chemistry 2013-04, Vol.288 (15), p.10923-10935
Hauptverfasser:	Lorenz, Matthew A., El Azzouny, Mahmoud A., Kennedy, Robert T., Burant, Charles F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - metabolism Animals Beta Cell Cell Line Energy Metabolism - drug effects Energy Metabolism - physiology Glucose - pharmacology Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - metabolism Intermediary Metabolism Lipid Metabolism - drug effects Lipid Metabolism - physiology Metabolism Metabolome - physiology Metabolomics Mice Sweetening Agents - pharmacology
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