Calcium, Bioenergetics, and Neuronal Vulnerability in Parkinson's Disease
The most distinguishing feature of neurons is their capacity for regenerative electrical activity. This activity imposes a significant mitochondrial burden, especially in neurons that are autonomously active, have broad action potentials, and exhibit prominent Ca2+ entry. Many of the genetic mutatio...
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Veröffentlicht in: | The Journal of biological chemistry 2013-04, Vol.288 (15), p.10736-10741 |
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Format: | Artikel |
Sprache: | eng |
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