Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

SAMHD1 is a dGTP-activated dNTPase that has been implicated as a modulator of the innate immune response. In monocytes and their differentiated derivatives, as well as in quiescent cells, SAMHD1 strongly inhibits HIV-1 infection and, to a lesser extent, HIV-2 and simian immunodeficiency virus (SIV)...

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Veröffentlicht in:	The Journal of biological chemistry 2013-04, Vol.288 (15), p.10406-10417
Hauptverfasser:	Yan, Junpeng, Kaur, Sarabpreet, DeLucia, Maria, Hao, Caili, Mehrens, Jennifer, Wang, Chuanping, Golczak, Marcin, Palczewski, Krzysztof, Gronenborn, Angela M., Ahn, Jinwoo, Skowronski, Jacek
Format:	Artikel
Sprache:	eng
Schlagworte:	HIV HIV Infections - enzymology HIV Infections - genetics HIV-1 - genetics HIV-1 - metabolism HIV-2 - genetics HIV-2 - metabolism Humans Innate Immunity Microbiology Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Protein Chemistry Protein Complexes Protein Multimerization Protein Structure, Quaternary Protein Structure, Tertiary Proteolysis SAM Domain and HD Domain-Containing Protein 1 Simian Immunodeficiency Virus - genetics Simian Immunodeficiency Virus - metabolism U937 Cells Virus
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