Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice

Testosterone (T) and its metabolites may underlie some beneficial effects for anxiety and cognition, but the mechanisms for these effects are unclear. T is reduced to dihydrotestosterone (DHT), which can be converted to 5α-androstane,3α,17β-diol (3α-diol) and/or 5α-androstane-3β,17β-diol (3β-diol)....

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Veröffentlicht in:	Hormones and behavior 2008-11, Vol.54 (5), p.726-734
Hauptverfasser:	Frye, Cheryl A., Koonce, Carolyn J., Edinger, Kassandra L., Osborne, Danielle M., Walf, Alicia A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3α-diol 3β-diol Adaptation, Ocular - drug effects Adaptation, Ocular - physiology Adaptation, Psychological - physiology Androgen Antagonists - pharmacology Androgens - pharmacology Androsterone Androsterone - pharmacology Animal behavior Animals Anti-Anxiety Agents - pharmacology Anxiety Anxiety - physiopathology Behavioral psychophysiology Biological and medical sciences Brain - drug effects Cognition Cognition & reasoning Cognition - drug effects Estrogen receptor beta Estrogen Receptor beta - agonists Estrogen Receptor beta - antagonists & inhibitors Estrogen Receptor beta - genetics Fundamental and applied biological sciences. Psychology Hormones and behavior Male Males Maze Learning - drug effects Maze Learning - physiology Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Neuropharmacology Nootropic Agents - pharmacology Pattern Recognition, Visual - drug effects Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopharmacology Rats Rats, Long-Evans Rodents Testosterone
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