Pomegranate Extracts in the Management of Men's Urologic Health : Scientific Rationale and Preclinical and Clinical Data
Multiple strands of research provide growing evidence that diet, nutrition, and life style play a role in the development and the course of urological diseases. Numerous micronutrients and polyphenols found in soy, green tea, and many fruits and vegetables have been described to impact diseases incl...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-9 |
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| creator | Kroeger, Nils Belldegrun, A. S. Pantuck, A. J. |
| description | Multiple strands of research provide growing evidence that diet, nutrition, and life style play a role in the development and the course of urological diseases. Numerous micronutrients and polyphenols found in soy, green tea, and many fruits and vegetables have been described to impact diseases including erectile dysfunction, benign prostatic hyperplasia, and prostate cancer. However, oftentimes these reports lack both a scientific rationale and supportive evidence base. The efficacy of pomegranate, on the other hand, in the modulation of central biological processes like inflammation, hypoxia, and oxidative stress that are important in the pathogenesis of urological maladies has been robustly demonstrated in preclinical in vitro and in vivo studies. Moreover, clinical trials have further supported its use in the treatment of several diseases, in particular in the management of prostate cancer. Herein, we critically review the scientific knowledge about the current role and future prospects for the use of pomegranate extracts in the therapy of erectile dysfunction, benign prostatic hyperplasia, and prostate cancer.Erratum to “Pomegranate Extracts in the Management of Men's Urologic Health: Scientific Rationale and Preclinical and Clinical Data”dx.doi.org/10.1155/2013/870454 |
| doi_str_mv | 10.1155/2013/701434 |
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S. ; Pantuck, A. J.</creator><contributor>Heber, David ; David Heber</contributor><creatorcontrib>Kroeger, Nils ; Belldegrun, A. S. ; Pantuck, A. J. ; Heber, David ; David Heber</creatorcontrib><description>Multiple strands of research provide growing evidence that diet, nutrition, and life style play a role in the development and the course of urological diseases. Numerous micronutrients and polyphenols found in soy, green tea, and many fruits and vegetables have been described to impact diseases including erectile dysfunction, benign prostatic hyperplasia, and prostate cancer. However, oftentimes these reports lack both a scientific rationale and supportive evidence base. The efficacy of pomegranate, on the other hand, in the modulation of central biological processes like inflammation, hypoxia, and oxidative stress that are important in the pathogenesis of urological maladies has been robustly demonstrated in preclinical in vitro and in vivo studies. Moreover, clinical trials have further supported its use in the treatment of several diseases, in particular in the management of prostate cancer. Herein, we critically review the scientific knowledge about the current role and future prospects for the use of pomegranate extracts in the therapy of erectile dysfunction, benign prostatic hyperplasia, and prostate cancer.Erratum to “Pomegranate Extracts in the Management of Men's Urologic Health: Scientific Rationale and Preclinical and Clinical Data”dx.doi.org/10.1155/2013/870454</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2013/701434</identifier><identifier>PMID: 23589721</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Antigens ; Benign ; Cancer therapies ; Clinical trials ; Consumption ; Disease prevention ; Diseases ; Erectile dysfunction ; Fruits ; Green tea ; Hyperplasia ; Hypoxia ; Inflammation ; Medical research ; Medical treatment ; Micronutrients ; Nonsteroidal anti-inflammatory drugs ; Nutrition ; Oxidative stress ; Phytochemicals ; Polyphenols ; Prostate ; Prostate cancer ; Radiation therapy ; Review ; Tea ; Urogenital system ; Urology ; Vegetables</subject><ispartof>Evidence-based complementary and alternative medicine, 2013-01, Vol.2013 (2013), p.1-9</ispartof><rights>Copyright © 2013 Kroeger N. et al.</rights><rights>Copyright © 2013 Kroeger N. et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2013 Kroeger N. et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-d065e02d58b75b12991191b0f2c49407f21d464ad89bca6f10337f41a339b2c73</citedby><cites>FETCH-LOGICAL-c466t-d065e02d58b75b12991191b0f2c49407f21d464ad89bca6f10337f41a339b2c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622365/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622365/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23589721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Heber, David</contributor><contributor>David Heber</contributor><creatorcontrib>Kroeger, Nils</creatorcontrib><creatorcontrib>Belldegrun, A. S.</creatorcontrib><creatorcontrib>Pantuck, A. J.</creatorcontrib><title>Pomegranate Extracts in the Management of Men's Urologic Health : Scientific Rationale and Preclinical and Clinical Data</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Multiple strands of research provide growing evidence that diet, nutrition, and life style play a role in the development and the course of urological diseases. Numerous micronutrients and polyphenols found in soy, green tea, and many fruits and vegetables have been described to impact diseases including erectile dysfunction, benign prostatic hyperplasia, and prostate cancer. However, oftentimes these reports lack both a scientific rationale and supportive evidence base. 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However, oftentimes these reports lack both a scientific rationale and supportive evidence base. The efficacy of pomegranate, on the other hand, in the modulation of central biological processes like inflammation, hypoxia, and oxidative stress that are important in the pathogenesis of urological maladies has been robustly demonstrated in preclinical in vitro and in vivo studies. Moreover, clinical trials have further supported its use in the treatment of several diseases, in particular in the management of prostate cancer. 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| subjects | Antigens Benign Cancer therapies Clinical trials Consumption Disease prevention Diseases Erectile dysfunction Fruits Green tea Hyperplasia Hypoxia Inflammation Medical research Medical treatment Micronutrients Nonsteroidal anti-inflammatory drugs Nutrition Oxidative stress Phytochemicals Polyphenols Prostate Prostate cancer Radiation therapy Review Tea Urogenital system Urology Vegetables |
| title | Pomegranate Extracts in the Management of Men's Urologic Health : Scientific Rationale and Preclinical and Clinical Data |
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