Heterochronic misexpression of Ascl1 in the Atoh7 retinal cell lineage blocks cell cycle exit

Retinal neurons and glia arise from a common progenitor pool in a temporal order, with retinal ganglion cells (RGCs) appearing first, and Müller glia last. The transcription factors Atoh7/Math5 and Ascl1/Mash1 represent divergent bHLH clades, and exhibit distinct spatial and temporal retinal express...

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Veröffentlicht in:	Molecular and cellular neuroscience 2013-05, Vol.54, p.108-120
Hauptverfasser:	Hufnagel, Robert B., Riesenberg, Amy N., Quinn, Malgorzata, Brzezinski, Joseph A., Glaser, Tom, Brown, Nadean L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascl1 Atoh7 Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Cell cycle Cell Cycle - genetics Cell Division Cell Lineage Gene Expression Regulation, Developmental Heterozygote Mice Mice, Inbred C57BL Mice, Transgenic Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurogenesis Neuroglia - cytology Neuroglia - metabolism Phenotype Retina - cytology Retina - growth & development Retina - metabolism Retinal cell competence Retinal ganglion cell Retinal Ganglion Cells - cytology Retinal Ganglion Cells - metabolism Retinal neurogenesis
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