TRAF6 regulates TCR signaling via interaction with and modification of LAT adapter

TNF receptor-associated factor 6 (TRAF6) is an essential ubiquitin E3 ligase in immune responses, but its function in adaptive immunity is not well understood. Here we show that TRAF6 is recruited to the peripheral ring of the T cell immunological synapse in Jurkat T cells or human primary CD4 + T c...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-03, Vol.190 (8), p.4027-4036
Hauptverfasser:	Xie, Ji-Ji, Liang, Jia-Qi, Diao, Liang-Hui, Altman, Amnon, Li, Yingqiu
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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