Detection and whole genome sequence analysis of an enterovirus 68 cluster
BACKGROUND: Enteroviruses are a common cause of human disease and are associated with a wide range of clinical manifestations. Enterovirus 68 is rarely detected yet was reported in many countries in 2010. Here enterovirus 68 was identified for the first time in New Zealand in 2010 and was detected i...
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| Veröffentlicht in: | Virology journal 2013-04, Vol.10 (1), p.103-103, Article 103 |
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| creator | Todd, Angela K Hall, Richard J Wang, Jing Peacey, Mathew McTavish, Sharla Rand, Christy J Stanton, Jo-Ann Taylor, Susan Huang, Q Sue |
| description | BACKGROUND: Enteroviruses are a common cause of human disease and are associated with a wide range of clinical manifestations. Enterovirus 68 is rarely detected yet was reported in many countries in 2010. Here enterovirus 68 was identified for the first time in New Zealand in 2010 and was detected in a further fourteen specimens over a six month period. OBJECTIVES: To genetically characterise enterovirus 68 specimens identified in New Zealand in 2010. STUDY DESIGN: The genome sequence of a New Zealand representative enterovirus 68 isolate was obtained. Ten clinical specimens were analysed by sequencing the VP1 region of the enterovirus 68 genome. RESULTS: Based on sequence analysis of the VP1 region and the full genome of one representative isolate, the New Zealand enterovirus 68 isolates clustered with contemporary enterovirus 68 viruses and do not show any clear distinguishing genetic diversity when compared to other strains. All fifteen specimens showed high similarity with enterovirus 68 by VP1 sequencing. The majority of New Zealand patients suffered from bronchiolitis, were less than two years of age and were of Pacific Island or Maori descent. CONCLUSIONS: We document the rare occurrence of an enterovirus 68 cluster in New Zealand in 2010. These viruses shared similarity with other clusters of enterovirus 68 that occurred globally in 2010. A greater awareness in enterovirus 68 infection may help detect this virus with increased frequency and enable us to better understand the role this strain plays in disease and the reasons behind this global emergence in 2010. |
| doi_str_mv | 10.1186/1743-422x-10-103 |
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Enterovirus 68 is rarely detected yet was reported in many countries in 2010. Here enterovirus 68 was identified for the first time in New Zealand in 2010 and was detected in a further fourteen specimens over a six month period. OBJECTIVES: To genetically characterise enterovirus 68 specimens identified in New Zealand in 2010. STUDY DESIGN: The genome sequence of a New Zealand representative enterovirus 68 isolate was obtained. Ten clinical specimens were analysed by sequencing the VP1 region of the enterovirus 68 genome. RESULTS: Based on sequence analysis of the VP1 region and the full genome of one representative isolate, the New Zealand enterovirus 68 isolates clustered with contemporary enterovirus 68 viruses and do not show any clear distinguishing genetic diversity when compared to other strains. All fifteen specimens showed high similarity with enterovirus 68 by VP1 sequencing. The majority of New Zealand patients suffered from bronchiolitis, were less than two years of age and were of Pacific Island or Maori descent. CONCLUSIONS: We document the rare occurrence of an enterovirus 68 cluster in New Zealand in 2010. These viruses shared similarity with other clusters of enterovirus 68 that occurred globally in 2010. A greater awareness in enterovirus 68 infection may help detect this virus with increased frequency and enable us to better understand the role this strain plays in disease and the reasons behind this global emergence in 2010.</description><identifier>ISSN: 1743-422X</identifier><identifier>EISSN: 1743-422X</identifier><identifier>DOI: 10.1186/1743-422x-10-103</identifier><identifier>PMID: 23548106</identifier><language>eng</language><publisher>England: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Analysis ; Child ; Child, Preschool ; Cluster Analysis ; DNA sequencing ; Enterovirus ; Enterovirus - genetics ; Enterovirus - isolation & purification ; Enterovirus Infections - epidemiology ; Enterovirus Infections - virology ; Enteroviruses ; Environmental science ; Female ; Genetic aspects ; Genetic research ; Genetic Variation ; genome ; Genome, Viral ; Genomes ; Genomics ; Health aspects ; Hospitals ; human diseases ; Humans ; Infant ; Male ; Microbiology ; Middle Aged ; Molecular Sequence Data ; New Zealand - epidemiology ; nucleotide sequences ; Nucleotide sequencing ; patients ; Phylogenetics ; Phylogeny ; Physiological aspects ; RNA, Viral - genetics ; sequence analysis ; Sequence Analysis, DNA ; Sequence Homology ; Viral genetics ; viruses ; Young Adult</subject><ispartof>Virology journal, 2013-04, Vol.10 (1), p.103-103, Article 103</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Todd et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Todd et al.; licensee BioMed Central Ltd. 2013 Todd et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b708t-b07571aa23278f283a8b13888e05188f0392abc7ef94564a9da4384ada44553b3</citedby><cites>FETCH-LOGICAL-b708t-b07571aa23278f283a8b13888e05188f0392abc7ef94564a9da4384ada44553b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621541/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621541/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23548106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Todd, Angela K</creatorcontrib><creatorcontrib>Hall, Richard J</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Peacey, Mathew</creatorcontrib><creatorcontrib>McTavish, Sharla</creatorcontrib><creatorcontrib>Rand, Christy J</creatorcontrib><creatorcontrib>Stanton, Jo-Ann</creatorcontrib><creatorcontrib>Taylor, Susan</creatorcontrib><creatorcontrib>Huang, Q Sue</creatorcontrib><title>Detection and whole genome sequence analysis of an enterovirus 68 cluster</title><title>Virology journal</title><addtitle>Virol J</addtitle><description>BACKGROUND: Enteroviruses are a common cause of human disease and are associated with a wide range of clinical manifestations. Enterovirus 68 is rarely detected yet was reported in many countries in 2010. Here enterovirus 68 was identified for the first time in New Zealand in 2010 and was detected in a further fourteen specimens over a six month period. OBJECTIVES: To genetically characterise enterovirus 68 specimens identified in New Zealand in 2010. STUDY DESIGN: The genome sequence of a New Zealand representative enterovirus 68 isolate was obtained. Ten clinical specimens were analysed by sequencing the VP1 region of the enterovirus 68 genome. RESULTS: Based on sequence analysis of the VP1 region and the full genome of one representative isolate, the New Zealand enterovirus 68 isolates clustered with contemporary enterovirus 68 viruses and do not show any clear distinguishing genetic diversity when compared to other strains. All fifteen specimens showed high similarity with enterovirus 68 by VP1 sequencing. The majority of New Zealand patients suffered from bronchiolitis, were less than two years of age and were of Pacific Island or Maori descent. CONCLUSIONS: We document the rare occurrence of an enterovirus 68 cluster in New Zealand in 2010. These viruses shared similarity with other clusters of enterovirus 68 that occurred globally in 2010. A greater awareness in enterovirus 68 infection may help detect this virus with increased frequency and enable us to better understand the role this strain plays in disease and the reasons behind this global emergence in 2010.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cluster Analysis</subject><subject>DNA sequencing</subject><subject>Enterovirus</subject><subject>Enterovirus - genetics</subject><subject>Enterovirus - isolation & purification</subject><subject>Enterovirus Infections - epidemiology</subject><subject>Enterovirus Infections - virology</subject><subject>Enteroviruses</subject><subject>Environmental science</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genetic research</subject><subject>Genetic Variation</subject><subject>genome</subject><subject>Genome, Viral</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>human diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>New Zealand - epidemiology</subject><subject>nucleotide sequences</subject><subject>Nucleotide sequencing</subject><subject>patients</subject><subject>Phylogenetics</subject><subject>Phylogeny</subject><subject>Physiological aspects</subject><subject>RNA, Viral - genetics</subject><subject>sequence analysis</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology</subject><subject>Viral genetics</subject><subject>viruses</subject><subject>Young Adult</subject><issn>1743-422X</issn><issn>1743-422X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkttr1UAQxoMo9qLvPmnAF31I3Wt28yKU4-1AQbAWfFs2eybpliRbd5Pa_vedeNraSAXZhVlmfvMxfDtZ9oKSA0p1-Y4qwQvB2GVBCV7-KNu9Tf14fO-9k-2ldEYIZ6WqnmY7jEuhKSl3s_UHGMGNPgy5HTb5r9PQQd7CEHrIE_ycYHCAFdtdJZ_y0OA7h2GEGC58nFJe6tx1U8LEs-xJY7sEz2_ifnby6eP31Zfi6Ovn9erwqKgV0WNREyUVtZZxpnTDNLe6plxrDURSrRvCK2Zrp6CphCyFrTZWcC0sBiElr_l-9n6rez7VPWwcThNtZ86j7228MsF6s6wM_tS04cLwklEpKAqstgK1D_8QWFZc6M1spZmtNJTg5ajy5maMGNCmNJreJwddZwcIUzKUCy20rIT6D5RJzrlgs-rrv9CzMEW0_zclBFeKiD9UazswfmgCzulmUXMouSjROVIhdfAAhWcDvXdhgMZjftHwdtGAzAiXY2unlMz6-NuSJVvWxZBShObOv9kf3M2HHHt5_-PuGm6XEYFXW6Cxwdg2-mROjhmhkhCGilLwa86C5Ro</recordid><startdate>20130402</startdate><enddate>20130402</enddate><creator>Todd, Angela K</creator><creator>Hall, Richard J</creator><creator>Wang, Jing</creator><creator>Peacey, Mathew</creator><creator>McTavish, Sharla</creator><creator>Rand, Christy J</creator><creator>Stanton, Jo-Ann</creator><creator>Taylor, Susan</creator><creator>Huang, Q Sue</creator><general>Springer-Verlag</general><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130402</creationdate><title>Detection and whole genome sequence analysis of an enterovirus 68 cluster</title><author>Todd, Angela K ; Hall, Richard J ; Wang, Jing ; Peacey, Mathew ; McTavish, Sharla ; Rand, Christy J ; Stanton, Jo-Ann ; Taylor, Susan ; Huang, Q Sue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b708t-b07571aa23278f283a8b13888e05188f0392abc7ef94564a9da4384ada44553b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cluster Analysis</topic><topic>DNA sequencing</topic><topic>Enterovirus</topic><topic>Enterovirus - genetics</topic><topic>Enterovirus - isolation & purification</topic><topic>Enterovirus Infections - epidemiology</topic><topic>Enterovirus Infections - virology</topic><topic>Enteroviruses</topic><topic>Environmental science</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Genetic research</topic><topic>Genetic Variation</topic><topic>genome</topic><topic>Genome, Viral</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>human diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>New Zealand - epidemiology</topic><topic>nucleotide sequences</topic><topic>Nucleotide sequencing</topic><topic>patients</topic><topic>Phylogenetics</topic><topic>Phylogeny</topic><topic>Physiological aspects</topic><topic>RNA, Viral - genetics</topic><topic>sequence analysis</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology</topic><topic>Viral genetics</topic><topic>viruses</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Todd, Angela K</creatorcontrib><creatorcontrib>Hall, Richard J</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Peacey, Mathew</creatorcontrib><creatorcontrib>McTavish, Sharla</creatorcontrib><creatorcontrib>Rand, Christy J</creatorcontrib><creatorcontrib>Stanton, Jo-Ann</creatorcontrib><creatorcontrib>Taylor, Susan</creatorcontrib><creatorcontrib>Huang, Q Sue</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Virology journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Todd, Angela K</au><au>Hall, Richard J</au><au>Wang, Jing</au><au>Peacey, Mathew</au><au>McTavish, Sharla</au><au>Rand, Christy J</au><au>Stanton, Jo-Ann</au><au>Taylor, Susan</au><au>Huang, Q Sue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection and whole genome sequence analysis of an enterovirus 68 cluster</atitle><jtitle>Virology journal</jtitle><addtitle>Virol J</addtitle><date>2013-04-02</date><risdate>2013</risdate><volume>10</volume><issue>1</issue><spage>103</spage><epage>103</epage><pages>103-103</pages><artnum>103</artnum><issn>1743-422X</issn><eissn>1743-422X</eissn><abstract>BACKGROUND: Enteroviruses are a common cause of human disease and are associated with a wide range of clinical manifestations. Enterovirus 68 is rarely detected yet was reported in many countries in 2010. Here enterovirus 68 was identified for the first time in New Zealand in 2010 and was detected in a further fourteen specimens over a six month period. OBJECTIVES: To genetically characterise enterovirus 68 specimens identified in New Zealand in 2010. STUDY DESIGN: The genome sequence of a New Zealand representative enterovirus 68 isolate was obtained. Ten clinical specimens were analysed by sequencing the VP1 region of the enterovirus 68 genome. RESULTS: Based on sequence analysis of the VP1 region and the full genome of one representative isolate, the New Zealand enterovirus 68 isolates clustered with contemporary enterovirus 68 viruses and do not show any clear distinguishing genetic diversity when compared to other strains. All fifteen specimens showed high similarity with enterovirus 68 by VP1 sequencing. The majority of New Zealand patients suffered from bronchiolitis, were less than two years of age and were of Pacific Island or Maori descent. CONCLUSIONS: We document the rare occurrence of an enterovirus 68 cluster in New Zealand in 2010. These viruses shared similarity with other clusters of enterovirus 68 that occurred globally in 2010. A greater awareness in enterovirus 68 infection may help detect this virus with increased frequency and enable us to better understand the role this strain plays in disease and the reasons behind this global emergence in 2010.</abstract><cop>England</cop><pub>Springer-Verlag</pub><pmid>23548106</pmid><doi>10.1186/1743-422x-10-103</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Analysis Child Child, Preschool Cluster Analysis DNA sequencing Enterovirus Enterovirus - genetics Enterovirus - isolation & purification Enterovirus Infections - epidemiology Enterovirus Infections - virology Enteroviruses Environmental science Female Genetic aspects Genetic research Genetic Variation genome Genome, Viral Genomes Genomics Health aspects Hospitals human diseases Humans Infant Male Microbiology Middle Aged Molecular Sequence Data New Zealand - epidemiology nucleotide sequences Nucleotide sequencing patients Phylogenetics Phylogeny Physiological aspects RNA, Viral - genetics sequence analysis Sequence Analysis, DNA Sequence Homology Viral genetics viruses Young Adult |
| title | Detection and whole genome sequence analysis of an enterovirus 68 cluster |
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