Single application of 4% dimeticone liquid gel versus two applications of 1% permethrin creme rinse for treatment of head louse infestation: a randomised controlled trial
A previous study indicated that a single application of 4% dimeticone liquid gel was effective in treating head louse infestation. This study was designed to confirm this in comparison with two applications of 1% permethrin. We have performed a single centre parallel group, randomised, controlled, o...
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| Veröffentlicht in: | BMC dermatology 2013-04, Vol.13 (1), p.5-5, Article 5 |
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| description | A previous study indicated that a single application of 4% dimeticone liquid gel was effective in treating head louse infestation. This study was designed to confirm this in comparison with two applications of 1% permethrin.
We have performed a single centre parallel group, randomised, controlled, open label, community based trial, with domiciliary visits, in Cambridgeshire, UK. Treatments were allocated through sealed instructions derived from a computer generated list. We enrolled 90 children and adults with confirmed head louse infestation analysed by intention to treat (80 per-protocol after 4 drop outs and 6 non-compliant). The comparison was between 4% dimeticone liquid gel applied once for 15 minutes and 1% permethrin creme rinse applied for 10 minutes, repeated after 7 days as per manufacturer's directions. Evaluated by elimination of louse infestation after completion of treatment application regimen.
Intention to treat comparison of a single dimeticone liquid gel treatment with two of permethrin gave success for 30/43 (69.8%) of the dimeticone liquid gel group and 7/47 (14.9%) of the permethrin creme rinse group (OR 13.19, 95% CI 4.69 to 37.07) (p < 0.001). Per protocol results were similar with 27/35 (77.1%) success for dimeticone versus 7/45 (15.6%) for permethrin. Analyses by household gave essentially similar outcomes.
The study showed one 15 minute application of 4% dimeticone liquid gel was superior to two applications of 1% permethrin creme rinse (p < 0.001). The low efficacy of permethrin suggests it should be withdrawn.
Current Controlled Trials ISRCTN88144046. |
| doi_str_mv | 10.1186/1471-5945-13-5 |
| format | Article |
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We have performed a single centre parallel group, randomised, controlled, open label, community based trial, with domiciliary visits, in Cambridgeshire, UK. Treatments were allocated through sealed instructions derived from a computer generated list. We enrolled 90 children and adults with confirmed head louse infestation analysed by intention to treat (80 per-protocol after 4 drop outs and 6 non-compliant). The comparison was between 4% dimeticone liquid gel applied once for 15 minutes and 1% permethrin creme rinse applied for 10 minutes, repeated after 7 days as per manufacturer's directions. Evaluated by elimination of louse infestation after completion of treatment application regimen.
Intention to treat comparison of a single dimeticone liquid gel treatment with two of permethrin gave success for 30/43 (69.8%) of the dimeticone liquid gel group and 7/47 (14.9%) of the permethrin creme rinse group (OR 13.19, 95% CI 4.69 to 37.07) (p < 0.001). Per protocol results were similar with 27/35 (77.1%) success for dimeticone versus 7/45 (15.6%) for permethrin. Analyses by household gave essentially similar outcomes.
The study showed one 15 minute application of 4% dimeticone liquid gel was superior to two applications of 1% permethrin creme rinse (p < 0.001). The low efficacy of permethrin suggests it should be withdrawn.
Current Controlled Trials ISRCTN88144046.</description><identifier>ISSN: 1471-5945</identifier><identifier>EISSN: 1471-5945</identifier><identifier>DOI: 10.1186/1471-5945-13-5</identifier><identifier>PMID: 23548062</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adolescent ; Adult ; Analysis of Variance ; Animals ; Child ; Child, Preschool ; Clinical trials ; Dimethylpolysiloxanes - administration & dosage ; Drug Administration Schedule ; Female ; Gels - administration & dosage ; Humans ; Insecticides - administration & dosage ; Lice Infestations - drug therapy ; Male ; Middle Aged ; Pediculus ; Permethrin - administration & dosage ; Treatment Outcome ; Young Adult</subject><ispartof>BMC dermatology, 2013-04, Vol.13 (1), p.5-5, Article 5</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Burgess et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Burgess et al.; licensee BioMed Central Ltd. 2013 Burgess et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b543t-870d3391d4e7b3f3fe4e2e1462682b1f3619638b3362327e14a007faa79eee353</citedby><cites>FETCH-LOGICAL-b543t-870d3391d4e7b3f3fe4e2e1462682b1f3619638b3362327e14a007faa79eee353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620921/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620921/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,24805,27928,27929,53795,53797,75742,75743</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23548062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burgess, Ian F</creatorcontrib><creatorcontrib>Brunton, Elizabeth R</creatorcontrib><creatorcontrib>Burgess, Nazma A</creatorcontrib><title>Single application of 4% dimeticone liquid gel versus two applications of 1% permethrin creme rinse for treatment of head louse infestation: a randomised controlled trial</title><title>BMC dermatology</title><addtitle>BMC Dermatol</addtitle><description>A previous study indicated that a single application of 4% dimeticone liquid gel was effective in treating head louse infestation. This study was designed to confirm this in comparison with two applications of 1% permethrin.
We have performed a single centre parallel group, randomised, controlled, open label, community based trial, with domiciliary visits, in Cambridgeshire, UK. Treatments were allocated through sealed instructions derived from a computer generated list. We enrolled 90 children and adults with confirmed head louse infestation analysed by intention to treat (80 per-protocol after 4 drop outs and 6 non-compliant). The comparison was between 4% dimeticone liquid gel applied once for 15 minutes and 1% permethrin creme rinse applied for 10 minutes, repeated after 7 days as per manufacturer's directions. Evaluated by elimination of louse infestation after completion of treatment application regimen.
Intention to treat comparison of a single dimeticone liquid gel treatment with two of permethrin gave success for 30/43 (69.8%) of the dimeticone liquid gel group and 7/47 (14.9%) of the permethrin creme rinse group (OR 13.19, 95% CI 4.69 to 37.07) (p < 0.001). Per protocol results were similar with 27/35 (77.1%) success for dimeticone versus 7/45 (15.6%) for permethrin. Analyses by household gave essentially similar outcomes.
The study showed one 15 minute application of 4% dimeticone liquid gel was superior to two applications of 1% permethrin creme rinse (p < 0.001). The low efficacy of permethrin suggests it should be withdrawn.
Current Controlled Trials ISRCTN88144046.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical trials</subject><subject>Dimethylpolysiloxanes - administration & dosage</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Gels - administration & dosage</subject><subject>Humans</subject><subject>Insecticides - administration & dosage</subject><subject>Lice Infestations - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pediculus</subject><subject>Permethrin - administration & dosage</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1471-5945</issn><issn>1471-5945</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1UstuFDEQtBCIhMCVI7KEcpzg17w4IK0iXlIkDsDZ8ozbu4489sT2BPFLfCWeJCwbEeSDW13V5XJ3I_SSkjNKu-YNFS2t6l7UFeVV_Qgd7xOPD-Ij9CylS0Jo29H6KTpivBYdadgx-vXV-q0DrObZ2VFlGzwOBotTrO0E2Y7BA3b2arEab8Hha4hpSTj_CIclaa2hp3iGWIp20Xo8RpgAlygBNiHiHEHlCXxeqTtQGruwFMx6AynfqLzFCkfldZhsAo3L0zkG50qYo1XuOXpilEvw4u4-Qd8_vP92_qm6-PLx8_nmohpqwXPVtURz3lMtoB244QYEMKCiYU3HBmp4Q_uGdwPnDeOsLYgipDVKtT0A8JqfoHe3uvMyTKDH4jkqJ-doJxV_yqCsvI94u5PbcC2LIOkZLQKbW4HBhv8I3EfGMMl1VnKdlaRcriZe35mI4WopHZKXYYm-_LvgTAhCKWN_WVvlQJZWhqI3lvaNclNz0XDSdqvW2QOscjRMNwM2tuQfKhhjSCmC2XunRK5r96_bV4ct29P_7Bn_DVEx1SA</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Burgess, Ian F</creator><creator>Brunton, Elizabeth R</creator><creator>Burgess, Nazma A</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20130401</creationdate><title>Single application of 4% dimeticone liquid gel versus two applications of 1% permethrin creme rinse for treatment of head louse infestation: a randomised controlled trial</title><author>Burgess, Ian F ; Brunton, Elizabeth R ; Burgess, Nazma A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b543t-870d3391d4e7b3f3fe4e2e1462682b1f3619638b3362327e14a007faa79eee353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical trials</topic><topic>Dimethylpolysiloxanes - administration & dosage</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Gels - administration & dosage</topic><topic>Humans</topic><topic>Insecticides - administration & dosage</topic><topic>Lice Infestations - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pediculus</topic><topic>Permethrin - administration & dosage</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burgess, Ian F</creatorcontrib><creatorcontrib>Brunton, Elizabeth R</creatorcontrib><creatorcontrib>Burgess, Nazma A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burgess, Ian F</au><au>Brunton, Elizabeth R</au><au>Burgess, Nazma A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single application of 4% dimeticone liquid gel versus two applications of 1% permethrin creme rinse for treatment of head louse infestation: a randomised controlled trial</atitle><jtitle>BMC dermatology</jtitle><addtitle>BMC Dermatol</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>13</volume><issue>1</issue><spage>5</spage><epage>5</epage><pages>5-5</pages><artnum>5</artnum><issn>1471-5945</issn><eissn>1471-5945</eissn><abstract>A previous study indicated that a single application of 4% dimeticone liquid gel was effective in treating head louse infestation. This study was designed to confirm this in comparison with two applications of 1% permethrin.
We have performed a single centre parallel group, randomised, controlled, open label, community based trial, with domiciliary visits, in Cambridgeshire, UK. Treatments were allocated through sealed instructions derived from a computer generated list. We enrolled 90 children and adults with confirmed head louse infestation analysed by intention to treat (80 per-protocol after 4 drop outs and 6 non-compliant). The comparison was between 4% dimeticone liquid gel applied once for 15 minutes and 1% permethrin creme rinse applied for 10 minutes, repeated after 7 days as per manufacturer's directions. Evaluated by elimination of louse infestation after completion of treatment application regimen.
Intention to treat comparison of a single dimeticone liquid gel treatment with two of permethrin gave success for 30/43 (69.8%) of the dimeticone liquid gel group and 7/47 (14.9%) of the permethrin creme rinse group (OR 13.19, 95% CI 4.69 to 37.07) (p < 0.001). Per protocol results were similar with 27/35 (77.1%) success for dimeticone versus 7/45 (15.6%) for permethrin. Analyses by household gave essentially similar outcomes.
The study showed one 15 minute application of 4% dimeticone liquid gel was superior to two applications of 1% permethrin creme rinse (p < 0.001). The low efficacy of permethrin suggests it should be withdrawn.
Current Controlled Trials ISRCTN88144046.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23548062</pmid><doi>10.1186/1471-5945-13-5</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PubMed Central Open Access; Springer Nature OA Free Journals; Access via BioMed Central; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adolescent Adult Analysis of Variance Animals Child Child, Preschool Clinical trials Dimethylpolysiloxanes - administration & dosage Drug Administration Schedule Female Gels - administration & dosage Humans Insecticides - administration & dosage Lice Infestations - drug therapy Male Middle Aged Pediculus Permethrin - administration & dosage Treatment Outcome Young Adult |
| title | Single application of 4% dimeticone liquid gel versus two applications of 1% permethrin creme rinse for treatment of head louse infestation: a randomised controlled trial |
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